| Objective: In this study,we analyzed the influence of luck factors on the constitution of patients with post-stroke depression at birth and the correlation with post-stroke depression with liver depression and spleen deficiency,so as to provide reference for the prevention and treatment of post-stroke depression.To explore the clinical effect of Yunqi Fang Lingzhu Decoction on post-stroke depression with liver depression and spleen deficiency,and to explore the clinical application scope of Yunqi Fang.Methods:The gender,age,date of birth,date of onset and other medical records of 124 patients with post-stroke depression in Ren Yinnian were collected,and the luck factors such as birth year,Si Tianzaiquan,and onset were statistically analyzed.According to the random number table method,90 patients with post-stroke depression of liver stagnation and spleen deficiency type who met the inclusion criteria were divided into Chinese medicine group A(31 cases),Chinese medicine group B(29 cases)and control group(30cases).During the study,6 cases were lost,and finally 29 cases of Chinese medicine group A,28 cases of Chinese medicine group B and 27 cases of control group were included for observation.Among them,the control group was treated with sertraline hydrochloride tablets on the basis of western medicine,the Chinese medicine group A was treated with Lingzhu Decoction on the basis of the control group,and the Chinese medicine group B was treated with Xiaoyao Powder on the basis of the control group.The total course of treatment was 2 weeks.The changes of TCM syndrome score,Hamilton Depression Scale(HAMD-17),National Institutes of Health Stroke Scale(NIHSS),Montgomery-Asberg Depression Scale(MADRS)score and serum hypersensitive C-reactive protein(hs-CRP)level were compared among the three groups before and after 2 weeks of treatment.The clinical efficacy of the three groups was observed.All data were analyzed by SPSS21.0 software.Results: 1.Luck factors: The birth year of 124 patients with post-stroke depression was too much,Shaoyang Xianghuo Sitian,Jueyin Fengmu Zaiquan,and the difference was statistically significant by chi-square fitting test(P<0.01).Logistic regression analysis showed that the risk of post-stroke depression of liver depression and spleen deficiency type was 1.728 times for those born with earth transport,2.251 times for those born with excessive earth transport,and 1.391 times for those born with excessive fire transport.The risk of post-stroke depression in patients with Shaoyang Xianghuo and Jueyin Fengmu in Sitian Spring was 1.705 times;the risk of post-stroke depression in patients with liver depression and spleen deficiency was 1.627 times,and the difference was significant(P<0.05).2.TCM syndrome score: There was no significant difference in TCM syndrome scores between the three groups before treatment(P>0.05),which was comparable.After 2 weeks of treatment,the scores of TCM syndromes in the three groups were lower than before.The scores of TCM syndromes after treatment in group A(13.00±2.85)were significantly lower than those in group B(15.57±2.27)and control group(16.37±2.15).The difference was statistically significant(P<0.01),and there was a significant difference between the scores before and after treatment in each group(P<0.01).It is suggested that the Chinese medicine group A is superior to the Chinese medicine group B and the control group in improving the syndrome of liver stagnation and spleen deficiency.3.HAMD-17 score: There was no significant difference in HAMD-17 scores between the three groups before treatment(P>0.05).After 2 weeks of treatment,the HAMD-17 scores of the three groups were lower than before.The HAMD-17 score of the patients in the Chinese medicine group A(13.03±2.80)was significantly lower than that of the Chinese medicine group B(16.43±2.43)and the control group(17.52±2.29).The difference was statistically significant(P<0.01).There was a significant difference before and after treatment in each group(P<0.01).It is suggested that Chinese medicine group A is more effective than Chinese medicine group B and control group in improving patients ’ depression.4.NIHSS score: There was no significant difference in NIHSS score between the three groups before treatment(P>0.05).After 2 weeks of treatment,the NIHSS scores of the three groups were reduced to varying degrees.The NIHSS score(4.24±2.40)after treatment in the Chinese medicine group A was significantly lower than that in the Chinese medicine group B(5.96±2.89)and the control group(6.70±2.71).The scores after treatment were statistically significant(P<0.01),and there was a significant difference before and after treatment in each group(P<0.01).It is suggested that group A is more helpful to the recovery of stroke in patients with post-stroke depression than group B and control group.5.MADRS score: There was no significant difference in MADRS scores between the three groups before treatment(P>0.05).After 2 weeks of treatment,the MADRS scores of the three groups were lower than before.The MADRS score of the patients in the Chinese medicine group A(13.31±3.70)was significantly lower than that of the Chinese medicine group B(16.86±2.84)and the control group(18.07±2.72).The difference was statistically significant(P<0.01),and there was a significant difference between each group before and after treatment(P<0.01).It is suggested that Chinese medicine group A can better improve the depression of patients than Chinese medicine group B and control group.6.Hs-CRP level: There was no significant difference in serum hs-CRP levels between the three groups before treatment(P>0.05).After 2 weeks of treatment,the serum hs-CRP levels of the three groups of patients decreased to a certain extent.The serum hs-CRP level(5.07±2.78)in the Chinese medicine group A after treatment was significantly lower than that in the Chinese medicine group B(9.14±7.20)and the control group(9.90±4.79).The serum hs-CRP level after treatment was statistically significant(P< 0.01),and there was a significant difference before and after treatment in each group(P<0.01).It is suggested that Chinese medicine group A can significantly reduce serum hs-CRP level.7.Clinical efficacy: After 2 weeks of treatment,the total effective rate of Chinese medicine group A was 89.65 %;the total effective rate of B group was 82.14 %.The total effective rate of the control group was 77.77 %.Conclusions:1.Birth year is too much soil transport,Shaoyang phase fire Sitian,Jueyin wind wood in the spring,the time of onset is the four qi,the main qi is Taiyin wet soil and other factors of the liver depression and spleen deficiency type of post-stroke depression susceptibility is high.The time of onset is three qi,the main qi is Shaoyang ministerial fire,the time of onset is the final qi,and the main qi is the sun cold water.The susceptibility of post-stroke depression with liver depression and spleen deficiency is low.2.Yunqi Fanglingzhu Decoction is effective in treating post-stroke depression patients with liver depression and spleen deficiency who were born with Taitu.It can significantly reduce their TCM syndrome score,HAMD-17 score,NIHSS score,MADRS score and serum hs-CRP level,improve depression,promote neurological function recovery and reduce serum inflammatory response.3.In the treatment of post-stroke depression with liver depression and spleen deficiency in Renyin years,Lingshu Decoction combined with the theory of five movements and six qi,considering the influence of time factors on the disease,the curative effect is better than that of Xiaoyao Powder and sertraline hydrochloride alone,and there is no obvious adverse reaction. |
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