Clinical Study Of Jiawei Xia Yu Xue Formula Combined With The Blood Pricking Therapy In The Treatment Of Hepatitis B Cirrhosis In Compensated Stage (Blood Stasis Blocking Collateral Type)

Objective: To evaluate the clinical efficacy of modified Yu Xue granules combined with punctured collaterals therapy in the treatment of compensatory stage of liver cirrhosis with blood stasis and to evaluate its efficacy and safety in the treatment of liver cirrhosis.Methods: By randomized,controlled experiment,105 patients according to:,were randomly divided into treatment group A,control group B and group C,patients in each group of 35 cases,control group C was treated with basic treatment,control group B was treated with basic treatment combined with modified Xiaoxue granules;Treatment group A was given combined puncture therapy on the basis of group B.After 24 weeks of trial,the changes of liver function,liver fibula,serological model(APRI,GPR)index,liver hardness,coagulation function and TCM syndrome score before and after treatment were observed,recorded and compared to evaluate its efficacy and safety.Results:(1)After 12 weeks and 24 weeks of the experiment,the liver function(ALT,AST)of the three groups before and after the experiment was observed.It was found that the liver function(ALT,AST)of the three groups decreased significantly than before the experiment(P< 0.05);ALT and AST in treatment group A were significantly improved compared with control group C(P< 0.05).ALT and AST in control group B were significantly improved compared with control group C(P< 0.05).(2)After 12 and 24 weeks of the experiment,four items of liver fibrosis and liver hardness values of the three groups were observed before and after the experiment,and it was found that the four items of serum liver fibrosis and liver hardness(LSM)indexes of the three groups were significantly decreased compared with those before the experiment(P< 0.05).Compared with control group B and control group C,the improvement of the four items of serum liver fiber in treatment group A was significant(P< 0.05).The improvement degree of serum LSM in treatment group A was significantly higher than that in control group C(P< 0.05).(3)After 24 weeks of the trial,liver coagulation function of the three groups of patients before and after the trial was observed and compared.It was found that the difference between patients in treatment group A and patients in control group B and control group C was not statistically significant(P> 0.05),indicating that the levels of PT and PTA in the three groups were not significantly improved.(4)After 24 weeks of the experiment,the observation and comparison of serum fibrosis APRI and GPR index of the three groups of patients before and after the experiment showed that the APRI and GPR index of the three groups of patients was P< 0.05 compared with that before the experiment,the difference was statistically significant,that is,the APRI and GPR index of the three groups of patients were effectively improved after the experiment;The decrease of A in treatment group was significantly better than that in control group B and control group C(P<0.05).(5)After 24 weeks of the experiment,the clinical efficacy of TCM in the three groups before and after the experiment was observed and compared.It was found that after treatment,treatment group A total effective rate: 85.71%.control B: 74.29%.control group C: 68.57%;and the TCM syndrome efficacy of treatment group A was better than that of control group B and control group C,and the difference was statistically significant(P<0.05);(6)After 24 weeks of the experiment,TCM syndrome scores of the three groups were observed and compared before and after treatment.It was found that the symptoms of the three groups were improved compared with that of the three groups(P<0.05),and the improvement degree of the treatment group A was more obvious than that of the control group C(P<0.05).Conclusions: 1.For patients with blood stasis and collateral-blocking type in the compensated stage of hepatitis B cirrhosis,the clinical effect of Jiawei Xianxue granule combined with collateral-puncture therapy combined with basic treatment is better,which is superior to the basic treatment and Jiawei Xianxue granule combined with basic treatment.The experiment showed that the combination of Yu Xue granules and pricking and arterial therapy combined with basic treatment can not only improve the serum liver fibrosis of patients,improve the liver function(ALT,AST)and other related indicators,but reduce the hardness of the liver,and can be a good treatment and reverse the development of cirrhosis.2.The combination of blood stasis granules with acupuncture and collaterals therapy under the added flavor can effectively improve the blood stasis symptoms of patients with liver cirrhosis in the compensatory period of blood stasis and collaterals,reducing the integral of TCM syndromes and further achieving good therapeutic effect.3.In the course of treatment,the combined treatment of Yu Blood granules with added flavor has good safety and no obvious adverse reactions.