Clinical Study On Jianpi Yiqi Mixture In The Treatment Of Functional Dyspepsia In Children With Spleen And Stomach Deficiency

Objective:To collect children with functional dyspepsia with spleen and stomach deficiency syndrome,and use Jianpi Yiqi Mixture for treatment.The effective rate after treatment and the recurrence rate after drug withdrawal were observed.To provide reference for the treatment of functional dyspepsia in children with traditional Chinese medicine.Methods:A randomized controlled trial was conducted from December 2021 to April 2022 in the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Fangchenggang Hospital of Traditional Chinese Medicine,Guilin Hospital of Traditional Chinese Medicine,Tiandong County Hospital of Traditional Chinese Medicine,Wuzhou Hospital of Traditional Chinese Medicine.150 children aged 3-14 years old with functional dyspepsia and spleen-stomach deficiency syndrome were collected(this study has been approved by the Hospital Ethics Committee,Ethics No.:Renshen 2021-036-02),using a random number table method.150 children were divided into treatment group and control group(142 cases were actually included,140 cases were finally completed due to shedding factors).Jianpi Yiqi mixture was used as the treatment group,and Jianwei Xiaoshi tablet was used as the control group.The treatment time was 2 weeks.The clinical symptoms before intervention,2 weeks after intervention and 2 weeks after intervention were scored.The single symptom score and total score were counted,and the effective rate and recurrence rate were calculated.Results:(1)Comparison of baseline data:After comparison,such a-s gender,age,course of disease and other demographic data,there was no statistical difference(P>0.05),and the data of the two groups could be compared with each other.(2)Comparison of total scores of TCM syndromes:Comparison b-etween groups:Before intervention,there was no significant difference in the total scores of TCM syndromes between the two groups(P>0.05).The scores of the two groups of syndromes could be compared afte-r intervention and after drug withdrawal.After 2 weeks of intervention and 2 weeks after the intervention,the total scores of TCM syndromes in the two groups were significantly different(P<0.05),which was statistically significant.Intra-group comparison:Treatment group:Compared with before intervention,there was a statistical difference after 2 weeks of intervention and 2 weeks after intervention(P<0.05).Compare-d with 2 weeks after intervention,there was no statistical difference af-ter 2 weeks of intervention(P>0.05).Control group:Compared with before intervention,there was statistical difference after 2 weeks of inte-rvention and 2 weeks after stopping intervention(P>0.05).(3)Comparison of single symptom scores:Comparison between gro-ups:Before the intervention,there was no statistical difference in the single symptom scores of traditional Chinese medicine between the two groups.After the intervention and two weeks after the intervention,there were significant differences between the two groups in the compari-son of 9 symptoms of epigastric fullness,epigastric pain,appetite,food intake,fatigue and weakness,weight and drowsiness,less gas and lazy words,sweating and loose stools(P<0.05).Comparison within the group:treatment group:after 2 weeks of intervention,the difference was statistically significant(P<0.05).The symptoms were:epigastric fullne-ss,epigastric pain,appetite,food intake,fatigue,belching and acid refl-ux,weight and drowsiness,less gas and lazy words,nausea and vomiti-ng,complexion,sweating,loose stools,poor stools,short yellow urine,restless night sleep;it shows that the treatment group has a certain e-ffect on improving the above 15 symptoms after 2 weeks of intervention.According to the results of rank sum test,after 2 weeks of intervention,the most obvious symptoms of symptom score decrease were epigastric pain,appetite and food intake;after 2 weeks of intervention,th-e most obvious symptoms of symptom score decrease were epigastric f-ullness,appetite and food intake.The control group:after 2 weeks of intervention,there were significant differences(P<0.05)in the symptoms of epigastric pain,epigastric fullness,appetite,food intake,fatigue,complexion,sweating,loose stools,short yellow urine,and sleep at night.It shows that the control group has a certain effect on improving th-e above 11 symptoms after 2 weeks of intervention.According to the results of rank sum test,after 2 weeks of intervention,the most obvious symptoms of the control group were epigastric fullness,appetite and food intake.After 2 weeks of intervention,the most obvious symptoms of the control group were epigastric fullness,appetite and food intake.(4)Comparison of disease efficacy:By comparing the integral chan-ges of the four main symptoms of epigastric fullness,epigastric pain,a-ppetite and food intake before and after intervention,the disease effica-cy was obtained.There were 71 cases in the treatment group,and the effective rate was 89.71%.There were 69 cases in the control group,and the effective rate was 68.12%.There was a significant difference between the two groups(P<0.05).(5)Comparison of TCM syndromes:After treatment,the effective rate of the treatment group was 97.00%.The effective rate of the control group was 75.00%,and the difference between the two groups was statistically significant(P<0.05).(6)Comparison of disease recurrence rate:After 2 weeks of intervention,compared with 2 weeks after intervention,there were 4 cases of recurrence in the treatment group,with a recurrence rate of 5.63%,an-d 12 cases of recurrence in the control group,with a recurrence rate o-f 17.39%.The recurrence rate of the treatment group was lower than that of the control group,and the difference was statistically significan-t(P<0.05).Conclusions:1.Jianpi Yiqi Mixture and Jianwei Xiaoshi Tablets hav-e curative effect on functional dyspepsia in children with spleen and st-omach deficiency syndrome.2.The efficacy of Jianpi Yiqi Mixture in the treatment of functional dyspepsia in children with spleen and stomach deficiency syndrome is better than that of Jianwei Xiaoshi Tablets group.3.Jianpi Yiqi Mixture has fewer adverse reactions and low recurren-ce rate in the treatment of functional dyspepsia in children with spleen and stomach deficiency syndrome,which is suitable for clinical application.