Clinical Study Of Nalbuphine Combined With Different Doses Of Midazolam To Prevent Shivering And Nausea And Vomiting During Cesarean Section

BackgroundBecause the pregnant women are a special group of patients,the anesthesia for cesarean section is also a special kind of anesthesia.In addition to the pregnant women themselves,the life of the fetus is also at risk of anesthesia.This special physiological feature determines that we use intraspinal anesthesia in clinical practice as one of the more appropriate anesthesia methods.The occurrence of chills further increases the maternal tension and discomfort;during the operation on the peritoneum pull,can cause patients with a great sense of discomfort,patients with mental tightness can cause restlessness,it may even increase the risk of intraoperative bleeding.Traction often causes nausea and vomiting reaction of patients,severe cases can cause severe fluctuations in vital signs,and even have to temporarily interrupt surgery,maternal and fetal life security posed a great threat.ObjectiveIn this study,full-term cesarean section women were given different doses of intravenous analgesia and sedative after delivery of the fetus to observe the occurrence of maternal shivering and nausea and vomiting during the operation,and to find a method of how to use adjuvant medication,reduce the complications of patients and improve the comfort of patients.MethodsPatients who underwent cesarean in our hospital between May 2021and May 2022were selected for this study,the patients were then randomly divided into three groups:GroupⅠ（0.1 mg/kg Nalbuphine+0.01 mg/kg Midazolam）,GroupⅡ（0.1 mg/kg Nalbuphine+0.02 mg/kg Midazolam）,and GroupⅢ（0.1 mg/kg Nalbuphine+0.03 mg/kg Midazolam）,there were 50 patients in each group.After the fetus is delivered,a dose of Nalbuphine and Midazolam was given intravenously.Blood Pressure（BP）,heart rate（HR）,pulse oxygen saturation（%）,respiratory rate（RR）,shivering grade,VAS score,Ramsay sedation score,nausea and vomiting were recorded at the time of into operating room（T1）,operation initiation（T2）,at childbirth（T3）,5 min after childbirth（T4）,exploration（T5）,peritoneum suturing（T6）,operation completion（T7）and 30 min after operation（T8）.Through the clinical study of 150 patients in three groups,we found a suitable adjuvant anesthesia for cesarean section,improve the comfort of patients and promote the recovery of patients.Results（1）There was no significant difference in the basic data between the three groups（P>0.05）.（2）The MAP（P>0.05）,and there was no statistical difference in MAP ratio at other time points inⅡgroups andⅢgroups（P>0.05）.（3）In terms of respiratory function,there was statistical difference betweenⅢgroups andⅠandⅡgroups at T₅、T₆、T₇（P>0.05）.（4）There was statistical difference in nausea and vomiting between groupⅠand groupⅡandⅢ（P<0.05）.Ⅱ,Ⅲwas no significant difference in shivering（P>0.05）;（6）The pull response of groupⅡ.Ⅲwas significantly better than that of group 1（P<0.05）;（7）Ramsay sedation score was increased at T₃and T₅（P<0.05）,T₄time point significantly increased Ramsay sedation score（P<0.01）.Conclusions:The recommended regimen for prevention of shivering and nausea and vomiting during cesarean section is 0.1 mg/kg of Nabufine hydrochloride plus 0.02 mg/kg of Midazolam.