| Objectives To explore the effect of duloxetine combined with group sandplay therapy on clinical symptoms and quality of life in patients with depression,and to provide new ideas and theoretical references for clinical diagnosis and treatment of depression,broadening the clinical application of group sandplay therapy.Methods A random sampling method was used to randomly divide 68 depressed patients who met the inclusion criteria into experimental and control groups,with 35 in the experimental groups and 33 in the control groups.The experimental groups were divided into group groups of 5 people in 1 group.The experimental group was treated with duloxetine combined with group sandplay therapy,while the control group was treated with duloxetine only.During the study,8 subjects dropped out for different reasons.Patients were assessed with the Hamilton Depression Scale(HAMD),the Hamilton Anxiety Scale(HAMA)and the WHO Quality of Life scale-BREF(WHOQOL-BREF)at baseline,at the end of Week 2,Week 4,and Week 8,respectively,to compare the clinical effect of the two intervention methods.The data were collected by IBM SPSS 24.0statistical software for statistical analysis.Results 1 Before treatment,there was no statistically significant difference in general data and HAMD,HAMA and QOL-BREF scores between the two groups(all P>0.05).2After 8 weeks treatment,the scores of HAMD,somatization,weight,cognitive impairment,retardation,sleep disturbance and despair factor decreased significantly with time(all P<0.05);There were significant differences in the scores of HAMD and somatization,retardation,sleep disturbance,despair factor between the experimental group and the control group(all P<0.05).At the end of the 2nd,4th and 8th week,the scores of HAMD,somatization and sleep disturbance factors in the experimental group were significantly lower than those in the control group(all P<0.05);At the end of the 4th week and the 8th week,the scores of depression and retardation factor in the experimental group were significantly lower than those in the control group(both P<0.05);There was significant difference in the score reduction rate between the two groups after treatment(Z=-2.032,P<0.05).3 The HAMA scores of the experimental group and the control group decreased significantly with the change of treatment time(both P<0.05);At the end of the 2nd,4th and 8th week,the HAMA scores of the experimental group were significantly lower than those of the control group(P<0.05).4 The QOL-BREF scores of the experimental group and the control group,as well as the G1,G4,physiological domains,psychological domains,social domains and environmental domains,were significantly decreased over time(all P<0.05).There were significant differences in QOL-BREF score,G1,G4,physiological domains and psychological domains between the experimental group and the control group at different time points(all P<0.05);The scores of G1 and environmental domains in the experimental group were significantly higher than those in the control group at the 4th and 8th week of treatment(both P<0.05);The scores of G4,physiological domain,psychological domain and social domain in the experimental group were significantly higher than those in the control group at the 2nd,4th and 8th weekends of treatment(all P<0.05);5 HAMD was positively correlated with HAMA(P<0.05).The higher the level of depression,the higher the score of anxiety.HAMD and HAMA were negatively correlated with QOL-BREF(P<0.05).The higher the score of depression and anxiety,the lower the score of quality of life.HAMD was negatively correlated with the score of psychological domains(P<0.05).The higher the score of depression,the lower the score of psychological domains.6 After intervention,the HAMD reduction rates of a certain group were as follows: A(81.5%),B(76.7%),C(77.3%),D(76.9%),E(80.0%).Conclusions 1 Duloxetine combined with group sandplay therapy was effective in improving depressive symptoms and superior to duloxetine alone in terms of somatization,retardation,sleep disturbance,and despair factor.2 Duloxetine combined with group sandplay therapy can effectively improve the anxiety symptoms of patients with depression,and the curative effect is better than that of duloxetine alone.3 Duloxetine combined with group sandplay therapy can effectively improve the quality of life of patients with depression,and the curative effect of quality of life in G1,G4,physiological domain,psychological domain and social domain is better than that of duloxetine alone.4 The higher the level of depression,the more serious the anxiety,and the worse the overall quality of life and the quality of life in the psychological domain.Figure8;Table12;Reference97... |
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