Study On The Relationship Between Autoimmune Thyroid Disease And Serum 25 Hydroxyvitamin D

Objectives Through clinical case-control study,observe the difference of serum 25(OH)d level between patients with autoimmune thyroid disease and normal physical examination,and further explore the role of vitamin D in the pathogenesis of autoimmune thyroid disease,so as to provide theoretical basis for treatment and prevention.Methods 68 patients with autoimmune thyroid diseases in the outpatient department and ward of the Endocrinology Department of the Affiliated Hospital of North China University of technology from November 2020 to November 2021 were selected as the case group,including 36 patients with Graves disease,32 patients with Hashimoto thyroiditis,and 68 healthy physical examiners in the Affiliated Hospital of North China University of technology in the same period as the healthy control group.68 patients were divided into AITD group,with an average age of 44.66±13.15 years,including 36patients with Graves disease and 32 patients with Hashimoto thyroiditis;There were 68cases in the healthy control group,with an average age of 46.72±10.55 years.The differences of vitamin D(25(OH)d),blood routine(WBC,RBC,HGB,PLT,HCT,MCV,MCH,MCHC),liver function(TP,ALB,PA,TBIL,DBIL,IBIL,ALT,AST,ALP,GGT),blood lipid(TC,TG,HDL-C,LDL-C)and other test indexes were compared.Application spss 21.0 statistical software for data analysis.The measurement data are tested for normality,which meets the normal distribution and variance homogeneity index,expressed as"mean±standard deviation";Count the data to calculate the constituent ratio or rate.Bilateral test,P<0.05,the difference was statistically significant.In the equilibrium analysis between the two groups,the constituent ratio or rate between the two groups was compared byχ~2 test;The mean between the two groups was compared by independent sample t-test.In multivariate analysis,the risk factors of autoimmune thyroid disease were screened by multivariate binary logistic regression analysis.Results 1 byχ~2 test analysis,there was no significant gender difference between the two groups(P>0.05).2 by independent sample t-test analysis,the age difference between the two groups was not statistically significant(P>0.05).3 by independent sample t-test analysis,there were significant differences in HGB,25(OH)d,ALT,AST,LDL-C and thyroid volume between the two groups(P<0.05).4 taking whether there is autoimmune thyroid disease as the dependent variable(yes=1,no=0)and the meaningful factors in the above analysis as the independent variable,25(OH)d is the influencing factor of autoimmune thyroid disease through multivariate logistic regression analysis(P<0.05).5by t-test analysis,there were significant differences in HGB,ALT,AST,TC,HDL-C and LDL-C between GD group and HT group in AITD group(P<0.05).6 taking whether they have Graves’disease and Hashimoto’s thyroiditis as dependent variables(GD=1,HT=0),and taking the meaningful factors and 25(OH)d in the above analysis as independent variables,through multivariate logistic regression analysis,it is concluded that the decrease of 25(OH)d level is the common influencing factor of Graves’disease and Hashimoto’s thyroiditis.Conclusions 1 The level of serum 25(OH)d in patients with autoimmune thyroid disease is low.2 25(OH)d deficiency may increase the risk of autoimmune thyroid disease.3 low 25(OH)d level may be a common influencing factor of Graves disease and Hashimoto thyroiditis.Figure0;Table12;Reference 155...