Clinical Observation On The Effect Of Liangxue Zhixue Decoction On The Prevention And Treatment Of Bleeding Of Colorectal Polyp After Endoscopic Resection

Objectives Observation on the clinical efficacy of Liangxue Zhixue Decoction to prevent bleeding after transendoscopic resection of colorectal polyps,and to provide integrated traditional Chinese and western medicine treatment ideas for the prevention and treatment of postoperative bleeding of colorectal polyp.Methods A total of 252 patients who underwent transendoscopic resection of colorectal polyps at the Department of Anorectal Medicine,Tangshan Hospital of Traditional Chinese Medicine from December 2020 to December 2021 were selected and randomly divided into a control group and a treatment group using the random number table method,with 126 cases included in both groups.Both groups were given preoperative bowel cleansing with polyethylene glycol electrolyte dispersion and given the same postoperative anti-inflammatory and rehydration regimen,with oral Liangxue Zhixue Decoction combined with intraoperative trauma clamping and harmonious clamping in the treatment group from 3 days preoperatively to the 7th postoperative day(not taken on the day of surgery),and intraoperative trauma clamping and harmonious clamping in the control group.General information such as gender composition,age profile,polyp diameter,location,time of surgery and number of harmonious clips were recorded separately for both groups.Post-operative haemoglobin level drop,first blood in stool symptom score,immediate and late post-operative bleeding rate and time to stop bleeding were used as indicators for post-operative bleeding evaluation in both groups.Trauma recovery assessed by endoscopic intestinal mucosal score at month 3 postoperatively;coagulation assessed by platelet content and activated partial thromboplastin time before and after treatment.The safety of the regimen was verified by changes in creatinine and transaminases before and after treatment.SPSS 19.0 software was used to carry out the analysis of the data for the above observation indicators.Results The general data of the two groups,including gender composition,age distribution,polyp location,diameter,pathological classification,operation time and the number of trauma clamping and harmonious clamping,were statistically analyzed and the differences between all general data were not statistically significant(P > 0.05)and were clinically comparable;The difference between the immediate and late postoperative bleeding rates of the two groups was statistically significant(P < 0.05),with the bleeding rate in the treatment group being lower than that in the control group;The difference between the immediate and late postoperative haemostasis times was statistically significant(P < 0.05),with the haemostasis time in the treatment group being shorter than that in the control group;The treatment group had a better first stool blood symptom score and lower haemoglobin level than the control group,with statistically significant differences(P < 0.05);The difference in platelet level and activated partial thromboplastin time between the two groups after treatment was statistically significant(P < 0.05);No statistically significant difference in endoscopic intestinal mucosal scores between the two groups at 3 months postoperatively(P > 0.05);During the treatment period,there were no adverse reactions or other conditions in either group.Conclusions The treatment of bleeding after endoscopic resection of colorectal polyps by Liangxue Zhixue Decoction can reduce the postoperative bleeding rate and shorten the hemostasis time,improve the degree of bleeding and increase the level of coagulation factors,but it cannot promote postoperative wound recovery.Figure 0;Table 20;Reference 119...