Correlation Study Of Intravenous Immunoglobulin In The Treatment Of Moderate To Severe Zoster-associated Pain

ObjectivesTo explore the correlation between intravenous immunoglobulin(IVIG)and moderate to severe zoster-associated pain(ZAP),providing a meaningful basis for clinical treatment.MethodsThis study is a cross-sectional study.The study participants were patients with moderate to severe ZAP who were treated in the Pain Department of our hospital from January 2015 to October 2021.According to the inclusion criteria and exclusion criteria,the final sample size was 785 cases.Based on clinical experience and previous literature conclusions,we initially included 32 covariates,and then selected 10 covariate filter modules from the covariate screening module of the Empowerstat Statistical Analysis Software to include the final model.In this study,the correlation between IVIG and moderate to severe ZAP efficacy was analyzed by a generalized multivariate linear regression model using IVIG treatment as the independent variable and the decrease in numerical scoring scale score decline in the three months after treatment as the dependent variable.And the results were verified by sensitivity analysis.In addition,through stratification analysis,we studied the effect of stratification of different covariates on the above correlations.ResultsResults of the study showed that IVIG treatment was positively correlated with the patient’s NRS decline in the model adjusted for 10 relevant covariates(β=0.46,95%CI:0.13 to 0.79,P<0.01).Sensitivity analysis verified the reliability of the above results.Stratification analysis showed that this positive correlation existed in the following stratifications:age>50 years;no prodromal pain;zero Charlson comorbidity score;the group with a high albumin/globulin ratio;CD4~+/CD8~+ratio;no oral amitriptyline;and acupuncture myofascial trigger point therapy.Conclusion1、There is a positive correlation between IVIG treatment and efficacy of moderate to severe ZAP.2、Factors such as age,production,Charlson’s comorbidity index,albumin/globulin ratio,CD4~+/CD8~+ratio,amitriptyline therapy,and acupuncture myofascial trigger point therapy had an impact on the positive correlation.