Analysis For Prognostic Factors Of 110 Cases Of Primary Liver Cancer With Interventional Therapy

Purpose: The mortality rate of primary liver cancer,one of the most prevalent malignant tumors in my nation,is second only to cancer.In recent years,the treatment of this malignancy has been continually advancing.Interventional treatment methods have drastically extended the survival time of primary liver cancer patients,and the rate of improvement has been to a certain degree.This study was conducted using 110 follow-up data from primary liver cancer patients treated with arterial chemotherapy embolism at Yan’an University’s auxiliary hospital.The risk or protective factors of the prognosis provided a reliable basis for the analysis.Clinical reasonable selection of adaptive certificates and improving the efficacy of intervention therapy.Methods: From January 1,2017 to December 31,2020,Yan’an University gathered a total of 110 primary liver cancer cases,all of which met the diagnostic criteria of the Primary Liver Cancer Diagnosis and Treatment Guidelines(2022 edition).These cases were then treated with arterialization embolism.All information is collected and classified through Microsoft Office Excel,and statistical analysis is performed using IBM SPSS Statistics 25.Kaplan-Meier’s method is employed to calculate the patient’s median survival time and the corresponding survival rate,and the survival function curve is then drawn.Single factor analysis is done using the Kaplan-Meier method and Log-Rank test,while multi-factor analysis is done through Cox analysis.Gradually,the proportional risk return model is returned and examined,thus screening for independent risk factors that could influence the prognosis of those with liver cancer.The analysis of single and multi-factor analysis is statistically significant with P < 0.05.Results: 1.A total of 110 cases were studied,with the median survival time being 15 months and the cumulative survival rates being 6,12,18,24 months were 80.0%,57.3%,34.5%,and 6.4%,respectively.2.Through consulting literature and information,collecting 17 factors related to the prognosis of TACE: sex;age;whether to diagnose primary liver cancer infected with viral hepatitis,regular antiviral treatment,whether there is liver cirrhosis;before TACE surgery Tumor metastasis,tumor numbers,tumor size,Child-Pugh grading,ascites,prothrombin time,albumin,bilirubin,AFP,AST;the number of embolism before the end of the follow-up time,treatment method,and actual survival time.Because all patients have viral hepatitis,the factor of viral hepatitis is no longer analyzed.Child-Pugh classification is based on hepatic brain disease,degree of ascites,and prothrombin time,albumin,and bilirubin levels.Therefore,the Child-Pugh grading is analyzed as a representative of the liver reserve function.Univariate analysis of the remaining 12 factors found that seven factors,including whether antiviral therapy,preoperative tumor metastasis,maximum tumor diameter,Child-Pugh grade,AFP,AST level,and number of embolisms,were associated with prognosis(P<0.05).3.The above 7factors are introduced into the Cox regression model,and the stepwise regression method is adopted in order to eliminate the mutual influence between each factor.Finally,four factors(P<0.05)significantly correlated with long-term prognosis were obtained,namely preoperative tumor metastasis,maximum tumor diameter,Child-Pugh grade,and AFP.Conclusion: 1.Interventional treatment was found to have a median survival time of15 months for primary liver cancer,with cumulative survival rates of 6,12,18 and 24 months being 80.0%,57.3%,34.5% and 6.4%,respectively.2.The prognosis of TACE in primary liver cancer patients was impacted by preoperative tumor metastasis,maximum tumor diameter,Child-Pugh grade,and AFP level independently.3.No tumor metastasis occurred before surgery,small tumor diameter,low Child-Pugh grade and low AFP level predicted that patients with primary liver cancer had a better prognosis and longer survival time after TACE.