Study On The Association Between Triglyceride Glucose Index And Stroke Risk

Stroke is a group of cerebrovascular diseases caused by organic brain damage,which has become the second leading cause of death and the third largest cause most common of disability in the world,and is also the first disabling and fatal disease threatening the health of Chinese residents.The best way to prevent and treat stroke is early detection,early diagnosis and early treatment.Therefore,it is particularly important to identify stroke patients early and find out their influencing factors.In recent years,as a simple,effective,economical and intuitive indicator to assess insulin resistance（IR）,the triglyceride glucose（TyG）index has been reported to be associated with many diseases（such as cardiovascular diseases）,but its relationship with stroke remains controversial.Objective:This study explored the relationship between TyG index and stroke risk based on existing research and data from the Early Screening and Comprehensive Intervention Program for Cardiovascular Disease High-risk Population in Jilin Province,with the aim of finding and identifying stroke patients as early as possible and taking targeted and effective interventions to ultimately reduce the disease burden and improve the national health level.Methods:Part 1:The electronic databases,including Pub Med,EMBASE,Cochrane Library,Web of Science and Medline,were searched from inception to November 2022 to explore the relationship between the TyG index and stroke risk.Rev Man 5.3 and Stata12.0 statistical software were used for statistical analysis.The effect estimates and 95%confidence intervals（CIs）were calculated using a random effects model and the generalized least-squares trend estimation was used to explore whether there was a potential dose-response relationship between the two.Part 2:In this study,the method of multistage stratified cluster sampling was adopted to sample the residents aged 35-75 in Changchun,and on-site questionnaire survey and physical examination were carried out.A multivariate logistic regression analysis method was used to explore the relationship between TyG index and the risk of stroke,and the method of restricted cubic spline was used to analyze whether there was a dose-response relationship between the two.Results:Part 1:A total of twenty studies were included in this study,involving seventeen cohort studies（12877394 participants）and three case-control studies/cross-sectional studies（287104 participants）.A higher TyG index increased the risk of stroke compared to a lower TyG index group（RR/HR=1.39,95%CI:1.27-1.51,P<0.001;OR=1.19,95%CI:1.07-1.32,P=0.001）.Furthermore,the results of the dose-response analysis of the cohort study demonstrated that the risk of stroke increased by 1.18 times per 1 mg/dl increment of the TyG index（RR=1.18,95%CI:1.11-1.24,P<0.001）.Subgroup analysis showed that TyG index was related to the occurrence of ischemic stroke（RR/HR=1.53,95%CI:1.21-1.94,P<0.001）,and the risk of stroke was higher in participants with basic diseases,women and those younger than 60 years old.Part 2:A total of 7374 permanent residents were investigated in this study,including 241 stroke patients and 7133 non-stroke patients.The prevalence of stroke was 3.27%,while the prevalence of stroke in Q1,Q2,Q3 and Q4 groups of TyG index was 2.44%,3.10%,3.30%and 4.23%respectively.TyG index was related to stroke(OR=1.77,95%CI:1.22-2.57,P_trend=0.003),and restricted cubic spline analysis showed no dose-response relationship between the two（P>0.05）.Subgroup analysis showed that this relationship was more obvious among women,60-75 years old,non-smokers and non-drinkers.Conclusions:1.Meta-analysis showed that TyG index is related to stroke,and a higher TyG index increases the risk of stroke.2.Current research showed that the prevalence of stroke among residents in Changchun City,Jilin Province is 3.27%,and TyG index is associated with the occurrence of stroke.