Clinical Efficacy And Safety Of Hyperbaric Oxygen Therapy For Diabetic Foot Ulcers: A Meta-analysis Of Randomized Controlled Clinical Trials

ObjectiveHyperbaric oxygen has been used to treat patients with diabetic foot skin ulcers for many years,but its clinical efficacy remains controversial.At present,most studies are clinical summary and retrospective analysis,and there is still a lack of evidence to satisfy the requirements of evidence-based medicine.Therefore,randomized controlled clinical trials of hyperbaric oxygen therapy for diabetic foot skin ulcers were included in this study to explore the efficacy and safety of hyperbaric oxygen therapy for diabetic foot patients through systematic evaluation and metaanalysis.Methods"Hyperbaric oxygen therapy,diabetic foot,random" was used to search all major Chinese and English databases established until December 2022,including Pub Med,Cochrane Library,Embase,Web of Science,CNKI,Wanfang Database and VIP database.Ulcer healing rate was the primary outcome index,while the secondary outcome indexes were effective rate,amputation rate,ulcer reduction area and adverse events.Literature screening,data extraction and bias risk assessment were conducted independently by two researchers.The meta-analysis was conducted with the aid of Rev Man 5.4 program.ResultsA total of 15 clinical studies involving 1142 patients were included.The results of meta-analysis showed that compared with the control group,the hyperbaric oxygen treatment group had significantly higher wound healing rate and effective rate than the control group,but there was no significant difference in the amputation rate.There was no increase in adverse reactions.ConclusionHyperbaric oxygen therapy can effectively promote the healing of diabetic foot wounds,improve the healing rate and effective rate,with good safety.