Correlation Between EOS,FeNO,total IgE And Lung Function In Patients With COPD And Their Application Value

Objective:By detecting peripheral blood EOS count,FeNO and serum total IgE levels in patients with COPD,the differences between peripheral blood EOS count,FeNO and serum total IgE levels in the acute exacerbation phase and stable phase were discussed,and their correlation with lung function was analyzed.Methods:Patients who were treated in the Department of Respiratory Medicine of the Second Affiliated Hospital of Nanchang University for chronic obstructive pulmonary disease from October 2021 to January 2023 were collected,and the cases were strictly screened according to the inclusion criteria and exclusion criteria,and a total of 119 patients were included,all of whom met the diagnostic criteria of the GOLD2022 version of the Guidelines for Chronic Obstructive Pulmonary Disease,and were divided into acute exacerbation and stable phase according to the diagnostic criteria.Patients in the stable phase were divided into mild,moderate,severe and very severe groups according to the percentage of first-second expiratory volume in lung function results,and named A,B,C,and D groups respectively.Among them,23 patients were in the acute exacerbation stage and 96 patients were in the stable stage.After coming to the hospital,the patient’s basic information such as gender,age,smoking history was collected,the informed consent form of biological samples was signed,and blood routine,lung function,FeNO,and serum total IgE tests were improved.SPSS 25.0 statistical software was used to analyze and compare the levels of peripheral blood EOS count,FeNO and serum total IgE between the groups,and the correlation with FEV1/FVC and FEV1% pred was analyzed by pearson correlation,and the ROC curve was plotted to analyze its value in predicting COPD exacerbation,and P<0.05 indicated that the difference was statistically significant.Results:1.A total of 119 patients were included,including 23 acute exacerbations and 96 stable patients,including 12 mild patients,27 moderate patients,32 severe patients and 25 very severe patients.There were no significant differences in age,sex composition,and smoking history between the acute exacerbation phase and the stable phase and the stable period(P>0.05).2.Comparison of peripheral blood EOS count,FeNO and serum total IgE level:the difference between peripheral blood EOS count and FeNO level in the acute exacerbation phase and the stable phase was not statistically significant(P>0.05),the serum total IgE level in the acute exacerbation period was higher than that in the stable phase,and the difference was statistically significant(P<0.05);the peripheral blood EOS count in the stable phase A,B,C,and D groups was not statistically significant(P>0.05);the FeNO and serum total IgE levels in the stable phase were compared.A<B<C<D,the difference was statistically significant(P<0.05).3.The correlation analysis results of pulmonary function and peripheral blood EOS count,FeNO and serum total IgE level during acute exacerbation showed that there was no significant correlation between FEV1/FVC and peripheral blood EOS count and FeNO level during acute exacerbation,and the correlation coefficients were0.173 and-0.143,respectively,which were not statistically significant(P>0.05),and were negatively correlated with serum total IgE level with moderate intensity.The correlation coefficient was-0.497,the difference was statistically significant(P<0.05),and the correlation coefficient of FEV1% pred in acute exacerbation was not significantly correlated with peripheral blood EOS count and FeNO level,and the correlation coefficients were 0.293 and-0.170,respectively,which were not statistically significant(P>0.05),and there was a moderate negative correlation with serum total IgE,and the correlation coefficient was-0.643,and the difference was statistically significant(P<0.05).4.The correlation analysis results between stable lung function and peripheral blood EOS count,FeNO and serum total IgE level showed that there was no significant correlation between stable phase FEV1/FVC and peripheral blood EOS count,the correlation coefficient was 0.057,the difference was not statistically significant(P>0.05),and there was a moderate negative correlation with FeNO and serum total IgE level,the correlation coefficients were-0.459 and-0.449,respectively,the difference was statistically significant(P<0.05),and the stable phase FEV1%There was no significant correlation between pred and peripheral blood EOS count,the correlation coefficient was 0.042,the difference was not statistically significant(P>0.05),and there was a moderate negative correlation with FeNO and serum total IgE levels,the correlation coefficients were-0.529 and-0.566,respectively,and the difference was statistically significant(P<0.05).5.The value of serum total IgE level in predicting COPD exacerbation showed that the area under the ROC curve(AUC)was 0.792,the corresponding sensitivity was 69.6%,the specificity was 77.1%,the Jordon index was 0.467,and the best cut-off value was 294.00 IU/ml,the difference was statistically significant(P<0.05).Conclusions:1.FeNO and serum total IgE levels in stable COPD patients were negatively correlated with lung function,suggesting that lung function may decline in patients with high levels of FeNO and serum total IgE.2.Total serum IgE level has a good predictive effect on COPD exacerbation,suggesting that serum total IgE may become a new auxiliary indicator for predicting COPD exacerbation.