Analysis Of Risk Factors For Intracranial Infection After Craniotomy For Acoustic Neuroma

Objective:Acoustic neuroma is a benign tumor with the highest incidence in cerebellopontine angle and posterior fossa,often invading the internal auditory tract and cerebellopontine angle,easily damaging nearby important anatomical structures and causing severe symptoms in patients.Thanks to the common development of surgical concepts and assistive technologies as well as the deepening of multidisciplinary cooperation,the treatment system of acoustic neuroma has been gradually improved.Currently,the main clinical treatment options include dynamic follow-up observation,stereotactic radiotherapy and microsurgery,with increasingly diverse options.However,microsurgery is still the preferred treatment for most acoustic neuroma patients.Due to the unique nature of the tumor,postoperative complications are easy to occur,then will reduce the quality of life of patients and affect the prognosis of patients.Through statistical analysis of medical records of patients with acoustic neuroma in our department,this paper discusses the risk factors affecting intracranial infection after microsurgery,providing reference for reducing intracranial infection in patients with acoustic neuroma clinically and improving prognosis.Methods:Data of 48 patients with acoustic neuroma admitted to the Department of Neurooncology,The First Hospital of Jilin University from January 2019 to July 2021 were collected and studied.All patients underwent surgical treatment and were confirmed as acoustic neuroma by postoperative pathology.After screening,46 cases were eventually included in this study.The basic information,surgical data,clinical data and postoperative follow-up data of patients were collected for descriptive analysis/retrospective analysis.Patient information was recorded in detail,including gender,age,date of hospitalization,date of operation,duration of operation,preoperative complications of diabetes,operator,intraoperative implants,preoperative prophylactic use of anti-inflammatory drugs,postoperative infection,and lumbar cisternosis drainage.SPSS 27.0 statistical analysis software was used for data analysis.The risk factors that may lead to intracranial infection were analyzed by single factor.Then,factors with statistical difference/significance in univariate analysis were included in multivariate analysis,and binary logistic regression analysis was used for processing.To explore the correlation between various influencing factors and postoperative intracranial infection.Finally,the high risk factors of intracranial infection were determined.P < 0.05,indicating statistical significance.Results:Among the 46 patients who met the inclusion criteria,the age ranged from 44 to71 years,with a mean of 55.8 years.Twenty patients were diagnosed with intracranial infection,with an infection rate of 43%.There were 13 cases of male(65%)and 7cases of female(35%).The infection rate of male was higher than that of female.The age ranged from 44 to 71 years,with a mean of 55.8 years.Univariate analysis showed that there were statistically significant differences between preoperative diabetes mellitus,lumbar cisternal catheter drainage,operation time,hospital stay,patient gender and postoperative infection(P<0.05),while there were no differences in tumor site,age,and infection rate of maximum menstrual cycle(P>0.05).In this study,it was found that gender of the patient and intraoperative lumbar cisternal drainage were independent risk factors for intracranial infection after acoustic neuroma.Conclusion:1.Resection of acoustic neuroma can effectively remove the occupying space and improve the status of patients,but the occurrence of postoperative intracranial infection cannot be ignored.This study found that gender of the patient,preoperative diabetes,intraoperative lumbar cisternal drainage,surgical duration,and hospital stay were risk factors for intracranial infection after acoustic neuroma resection.Patient gender and intraoperative lumbar cisternal drainage are independent risk factors for intracranial infection after acoustic neuroma.There was no statistical significance between tumor site,patient age,maximum tumor diameter and intracranial infection after acoustic neuroma resection.2.According to the results of this study,effective clinical prevention and treatment programs were proposed to reduce the occurrence of postoperative intracranial infection and improve the prognosis of patients.Inheriting and practicing the Bethune spirit,taking patients as the center and serving patients wholeheartedly is what doctors should adhere to.