Clinical Study On Huayu Tongluo Moxibustion For Improving Cognitive Function Decline In Ischemic Stroke And Its Effect On Plasma Hcy And Aβ_1-42

Objective:To explore the therapeutic effect of Huayu Tongluo moxibustion on cognitive decline caused by ischemic stroke by analyzing the changes of scales and serological indexes before and after treatment in patients with cognitive decline after ischemic stroke,so as to provide clinical basis for Huayu Tongluo moxibustion in the treatment of cognitive decline after ischemic stroke.Methods:A total of 60 patients with cognitive decline after ischemic stroke were randomly divided into a treatment group and a control group,30 cases in each group.The control group was treated with common drugs for clinical treatment of ischemic stroke,and the treatment group was treated with Huayu Tongluo moxibustion on the basis of the treatment of the control group.Addenbrooke’s Cognitive Examination-ⅲ（ACE-Ⅲ）,Brief Visuospatial Memory Test（BVMT-R）,digit span test（DST）and AIS were evaluated before and after treatment.The changes of homocysteine（Hcy）and amyloid-β1-42(Aβ_1-42)were detected before and after treatment.The measurement data were analyzed by t test（normal distribution）or non-parametric test（not normal distribution）,and were described by mean±standard deviation.Categorical data were analyzed by chi-square test and described by frequency N and constituent ratio%.SPSS 23.0 software was used for statistical analysis.Results:1.There were no significant differences in age,gender,course of disease,ACE-Ⅲscale,BVMT-R scale,DST scale,AIS scale,serum Hcy and Aβ_1-42 levels between the treatment group and the control group before treatment（P>0.05）,which were comparable.2.Comparison of ACE-Ⅲscore:ACE-Ⅲscore in the treatment group before and after treatment was significantly different（P<0.01）,while ACE-Ⅲscore in the control group before and after treatment was not significantly different（P>0.05）.3.Comparison of BVMT-R scores:there was no significant difference in BVMT-R scores between the treatment group and the control group before and after treatment（P>0.05）.4.Comparison of DST scores:there was significant difference in the DST scale before and after treatment in the treatment group（P<0.01）,but no significant difference in the control group（P>0.05）.5.Comparison of AIS score:the difference of AIS scale before and after treatment in the treatment group was statistically significant（P<0.01）,while the difference of AIS scale in the control group was not statistically significant（P>0.05）.6.Comparison of plasma Hcy levels:the plasma Hcy levels before and after treatment in the treatment group were significantly different（P<0.01）,and there was no significant difference in the plasma Hcy levels before and after treatment in the control group（P>0.05）.7.Comparison of plasma Aβ_1-42 level:there was significant difference in plasma Aβ_1-42 level before and after treatment in the treatment group（P<0.01）,but there was no significant difference in plasma Aβ_1-42 level before and after treatment in the control group（P>0.05）.Conclusion:1.Huayu Tongluo moxibustion therapy can significantly improve the cognitive function of patients with PSCI,improve the quality of daily life of patients,especially in improving the learning and memory ability of patients.（2）Plasma Hcy level was positively correlated with the degree of cognitive impairment in PSCI patients.Plasma Aβ1-42 level was negatively correlated with the degree of cognitive impairment in PSCI patients.（3）Moxibustion for removing stasis and clearing collaterality can significantly improve the sleep condition of patients with PSCI.