Clinical Observation On The Treatment Of CKD Stage 3-5 Non Dialysis Patients With Spleen And Kidney Qi Deficiency And Blood Stasis And Dampness Turbidity By Navel Therapy With Traditional Chinese Medicine

Objective:By observing the clinical effect of navel method in treating non-dialysis patients with CKD(stage 3～5)of spleen and kidney deficiency and blood stasis and dampness turbidity,understanding its influence on efficacy indexes,Safety indicators and RF indicators,and understanding the effect of umbilical therapy of Chinese medicine on CKD,In terms of clinical application,it lays a foundation for the treatment of CKD with integrated traditional Chinese and western medicine.Play the unique advantage of TCM umbilical prescription in the syndrome of spleen and kidney qi deficiency and blood stasis and turbidity.Methods:A total of 60 non-dialysis patients of CKD3-5 type with "deficiency of spleen and kidney qi and blood stasis and turbid dampness" were selected and randomly divided into treatment group and control group with 30 people respectively according to the principle of randomization,and signed informed consent respectively.Both sides carried out the following interventions: control of blood pressure(BP)and blood glucose(GLU),active intervention for primary diseases,correction of anemia,Excellent quality proper protein diet,correct water electrolyte acid-base balance,etc.Based on the above measures,the observation group,and the navel therapy is applied outside the navel,once a day,for 8 weeks.After 4 weeks of medication,The observation also requires the recording of safety indicators(AST,ALT,K,Ca,P,Routine blood test,routine urine test),RF related parameters(IL-6,IV-C)TCM syndrome score,renal function related parameters(Scr,Cys C,BUN,e GFR)were observed and recorded,hs-CRP indicators and safety indicators before and after 8 weeks of medication.Finally,comprehensively evaluate the clinical efficacy of the two groups of patients according to statistical analysis.The difference was statistically significant(P<0.05).Results:1.There was no statistically significant difference in baseline data of gender,age,course of disease,disease stage and primary disease between the two groups before treatment(P>0.05).2.After intervention,in the clinical ORR index,the control group was70%,and the experimental group was 90%,the latter was significantly higher(P<0.05).3.After intervention,the ORR of TCM syndromes improved by 50% in the control group and 80% in the experimental group,Curative effect of treatment group is better(P<0.05).Compared with before remedy,the total scores of TCM syndromes in control group and experimental group were significantly reduced after intervention(P<0.05).After intervention,the total scores of TCM syndromes were significantly different between the two groups(P<0.05).4.After treatment,there were statistically significant differences in Scr and e GFR between the two groups(P<0.001).After intervention,compared with the matched group,the experimental group had obvious advantages in improving Scr and e GFR(P<0.05).After intervention,the difference of Cys C and BUN indexes between the two groups was statistically significant(both P<0.05).After intervention,the experimental group was superior to the control group in both indicators(P<0.05).5.IL-6 decreased in both groups before and after treatment(P<0.05).After intervention,the experimental group had a significant advantage compared with the control group(P<0.05),and after treatment,the experimental group IV-C decreased(P<0.05);There was no significant change in IV-C in control group after treatment(P>0.05).Comparing the two groups after intervention,there was difference between the experimental group and the control group(P<0.05).6.The index of hs-CRP was not significantly different within the two groups before and after the intervention(P>0.05).Comparing the two groups after intervention,there was no evident difference in this index between the experimental group and the control group(P>0.05).7.There were no overt differences in AST,P,ALT,Ca and K within the two groups before and after intervention(P>0.05).After intervention,the comparison between groups showed that compared with the control group,the experimental group showed no evident difference in the above safety indicators(P>0.05).Conclusions:1.Umbilical therapy prescription has a significant effect on CKD3-5non-dialysis patients with spleen and kidney qi deficiency and blood stasis and dampness turbidity type,There is no obvious AR,and it has promotion value.2.Umbilical cord therapy can greatly improve the TCM syndrome of spleen and kidney qi deficiency and blood stasis in non-dialysis patients with CKD3-5,which has significant advantages over single Western medicine therapy.3.Umbilical therapy prescription can significantly improve the serum IL-6 and IV-C levels of non-dialysis patients with CKD3-5 type of spleen and kidney deficiency and blood stasis and dampness turbidity,It can greatly improve residual renal function,and delay the progress of renal fibrosis to a certain extent.