Clinical Data Analysis Of Cervical Cancer Aged 35 Years And Younger From 2016 To 2021

ObjectiveThe baseline data,clinical data,HPV infection,coagulation index,inflammatory index,tumor markers and clinicopathological data of cervical cancer patients aged 35 and below were discussed,and the incidence trend and clinical characteristics of young cervical cancer patients were found,so as to provide reference for the prevention and diagnosis and treatment evaluation of young cervical cancer patients.MethodsA retrospective analysis was performed on the clinical data of 197 patients who visited the Department of Gynecology of the First Hospital of Lanzhou University from January 2016 to December 2021.Among them,71 cases were in the case group,all of whom were patients aged 35 and below who were diagnosed with cervical cancer after the first diagnosis and treatment in our hospital;The 126 patients in the control group were all cervical cancer patients aged 60 and above who were diagnosed with cervical cancer for the first time in the same period,and the baseline data,clinical data,HPV infection,coagulation index,inflammatory index,tumor marker and clinicopathological data of the two groups were collected,and the data were statistically analyzed by SPSS 22.0 software.Results1.From January 2016 to December 2021,the overall incidence of cervical cancer patients in our hospital showed an upward trend.2.There were statistically significant differences between young cervical cancer group and control group in ethnicity,long-term residence,age of first sexual life,number of sexual partners,smoking history,history of oral contraceptives,number of pregnancies and births(P<0.05),and the differences in religious belief,work,BMI and drinking history between the two groups were not statistically significant.3.There were significant differences between the young cervical cancer group and the control group in clinical first symptoms,cervical morphology and HR-HPV infection sequence(P<0.05).There was no statistically significant difference in the complexity of HPV infection between the two groups.4.The difference between young cervical cancer group and control group in FIB,FAR,PLT,HE4 and SCC was statistically significant(P<0.05),and the difference between the two groups in blood group,ALB,N,E,L,SII,NLR,PLR,ELR and CA125 was not statistically significant.5.The difference between young cervical cancer group and control group in FIGO clinical stage and proliferation index Ki-67 was statistically significant(P<0.05),and the difference in pathological type,tissue differentiation degree and proliferation index P16 between the two groups was not statistically significant.Conclusions1.The incidence of young cervical cancer patients in our hospital increased from January 2016 to December 2021.2.The onset of young cervical cancer patients is related to the early age of first sexual life,multiple sexual partners,smoking history and history of oral contraceptives,and its clinical first symptoms are mostly contact bleeding,cervical morphology is mostly exophytic,and the most common three HR-HPV infection sequences are 16 type,58 type and 52 type,which has certain guiding significance for the development and vaccination of HPV vaccine for the prevention of cervical cancer in Gansu Province.3.The levels of FIB,FAR,HE4 and SCC in the young cervical cancer group were lower than those in the control group,but the PLT level was higher than that in the control group;Compared with the control group,FIGO had an earlier clinical stage and a lower proliferation index Ki-67 in the young cervical cancer group.