Analysis Of Short-Term And Long-Term Effect Of Uniportal Thoracoscopic Radical Resection Of Lung Cancer In Patients With Non-Small Cell Lung Cancer

Objective:(1)To compare the perioperative efficacy and short-term postoperative complications of uniportal thoracoscopic radical resection of lung cancer(UTRRLC)and three-port thoracoscopic radical resection of lung cancer(TTRRLC)in patients with non-small cell lung cancer(NSCLC).(2)To compare the long-term survival of NSCLC patients with UTRRLC and TTRRLC.(3)The QLQ-C30 and QLQ-LC13 scales were used to investigate and analyze the effects of UTRRLC and TTRRLC on the short-term postoperative quality of life of NSCLC patients.Methods:(1)Part Ⅰ: : The clinical data of 205 NSCLC patients who underwent UTRRLC or TTRRLC in the thoracic surgery department of Anhui Chest Hospital from January2015 to December 2016 were retrospectively analyzed,and the hospitalization number,name,gender,operation mode,tumor location,pathological type and other perioperative data were recorded.The clinicopathological features,perioperative data and long-term survival of UTRRLC and TTRRLC patients were compared.The Overall Survival(OS),OS of patients was obtained through telephone follow-up or outpatient review.All patient data were calculated by SPSS 26.0 statistical software.Check the normality of the data,the data conforming to the normal distribution are expressed byx±s,and the comparison of the mean of the measurement data is made by T test.The skewness data were described by the median M(P25,P75),and the comparison between the two groups was Wilcoxon rank sum test(statistics were u).χ2 test was used to compare the counting data.(2)Part Ⅱ: : Investigate and analyze the medical records of 30 NSCLC patients who underwent UTRRLC or TTRRLC in the thoracic surgery department of Anhui Chest Hospital from January 2022 to March 2022.Record the patient’s hospitalization number,sex,age,operation mode and perioperative data.In addition,QLQ-C30 and QLQ-LC13 scales were used to record the patients’ quality of life scores 1 day before operation,1week,2 weeks,4 weeks and 8 weeks after operation.All patient data were calculated by SPSS 26.0 statistical software.Comparison of quality of life scores for UTRRLC and those assessed at different times for TTRRLC patients using repeated measures ANOVA.Results:(1)Part Ⅰ: There was no statistical difference in the clinicopathological features between the two groups(P > 0.05).Compared with the TTRRLC,the UTRRLC had less postoperative drainage(P=0.002).the UTRRLC had shorter postoperative catheter holding time and shorter postoperative hospitalization time(P=0.001 and P<0.001).There was no statistical difference in the number of lymph node dissection stations between the UTRRLC and TTRRLC(P=0.058).The 24-hour pain score in the UTRRLC was significantly lower than that in the TTRRLC(P < 0.001).There was no significant difference in the total complication rate and pulmonary complication rate in UTRRLC and TTRRLC(P=0.161,P=0.275).The median survival time and the 1,3 and 5-year survival rates of UTRRLC were 63.0 months and 95.0%,75.2% and 51.5%,respectively,while the median survival time and the 1,3 and 5-year survival rates of TTRRLC were 61.0 months and 89.3%,70.9% and 50.5%,respectively,and there was no significant statistical difference between the two groups(P = 0.440).(2)Part Ⅱ: There was no statistical difference in the clinicopathological features between the two groups(P > 0.05).Compared with the TTRRLC,the UTRRLC had less postoperative drainage(P=0.008).The UTRRLC had shorter postoperative catheter holding time and shorter postoperative hospitalization time(P=0.001 and P<0.001).The patients in the UTRRLC had higher physical function,role function and emotional function at each node after operation than those in the TTRRLC(P < 0.05).The fatigue and pain symptoms of patients in UTRRLC were lower than those in TTRRLC in each node after operation.The overall health status of patients in UTRRLC was lower than that of patients in TTRRLC after operation(P < 0.05).Conclusions:(1)UTRRLC has the same therapeutic effect and is more minimally invasive than TTRRLC in the treatment of NSCLC patients.(2)There is no significant difference in long-term survival between UTRRLC and UTRRLC in NSCLC patients.(3)UTRRLC can make NSCLC patients recover faster and improve the quality of life after operation.