| Objective Obsessive-compulsive disorder is a chronic disabling disease.Studies have shown that adult obsessive-compulsive disorder is often accompanied by cognitive impairment.Therefore,this study explores the brain functional imaging features of patients with obsessive-compulsive disorder and its correlation with cognitive function,so as to provide evidence for the brain imaging mechanism of the cognitive impairment of obsessive-compulsive disorder.Methods In this study,15 patients with obsessive-compulsive disorder(OCD)and 21 matched healthy controls were included in the outpatient Department of Anxiety Disorders of Shenzhen Mental Health Center/ Shenzhen Kangning Hospital from October2022 to February 2023.Y-BOCS,HAMD,HAMA and MCCB were used to evaluate obsessive-compulsive symptoms,depressive symptoms,anxiety symptoms and cognitive function,and all enrolled subjects were examined by resting state functional magnetic resonance imaging.Results(1)In this study,the general and clinical data of 15 patients with obsessivecompulsive disorder and 21 healthy control group were compared,and the results showed that there was no statistical significance in age,sex and education between the two groups(P > 0.05).(2)(1)In this study,MCCB was used to evaluate the cognitive function of the obsessive-compulsive disorder group and the control group,and T-test was used to compare the cognitive function of the two groups.The results showed statistical differences in processing speed(P = 0.000),reasoning and problem-solving abilities(P =0.000),visual memory and learning(P = 0.013),social cognition(P = 0.012),and attentiveness/alertness(P = 0.000).(2)Pearson correlation analysis showed that the Re Ho value of the right caudate nucleus was positively correlated with speech learning and memory(r = 0.710,P < 0.01);The Re Ho of the right medial superior frontal gyrus was negatively correlated with the information processing speed(r = 0.662,P < 0.05).(3)The functional connections of the left precuneus and right paracentral lobule were positively correlated with reasoning and problem solving ability(r= 0.592,P < 0.05);The functional connections of right medial superior frontal gyrus and right superior marginal gyrus were not significantly associated with cognitive function(P > 0.05).(3)Compared with the control group,the brain regions in the obsessive-compulsive disorder group showed a significant decrease in local consistency in the right caudate nucleus during resting state.The brain regions with significantly increased local consistency were distributed in the left precuneus,left posterior central gyrus and right medial superior frontal gyrus,and the differences were statistically significant(After GRF correction P <0.05).(4)The whole brain functional connectivity analysis was conducted with the right caudate nucleus,left precuneus,left posterior central gyrus and right medial superior frontal gyrus as ROI,and the results showed that the functional connectivity between the right medial superior frontal gyrus and right superior limbic gyrus was weakened in the obsessive-compulsive disorder group.Functional connections between left precuneus and right paracentral lobules were enhanced(After GRF correction P < 0.05).Conclusion(1)(1)Patients with obsessive-compulsive disorder have multi-dimensional cognitive impairment,involving memory learning,processing speed,reasoning and problem solving ability.(2)In patients with obsessive-compulsive disorder,the abnormal local consistent activity in several brain regions is correlated with the cognitive function,suggesting that the change of cognitive function may be associated with the abnormal neural activity in the corresponding brain regions.(3)The changes of functional connections in the brain of patients with obsessive-compulsive disorder are related to their cognitive function,suggesting that abnormal functional connections in the brain may also be part of the cause of cognitive impairment.(2)Patients with obsessive-compulsive disorder have abnormal local consistent activity in several brain regions in the resting state,involving the caudate nucleus,precuneus and other brain regions with core executive function.(3)Forced patients with abnormal functional connection strength of brain regions,suggesting that patients with obsessive-compulsive disorder may not only involve a single brain region caused by abnormal activity. |
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