Study On The Medication Pattern Of Chronic Atrophic Gastritis With Intestinal Epithelial Metaplasia By Professor Xie Jingri Using The Elimination And Tonic Method

Obj ective:To retrospectively analyze and summarize the clinical cases of patients with chronic atrophic gastritis with intestinal metaplasia treated by Professor Xie Jingri,using the Traditional Chinese Medicine Inheritance Calculation Platform System(V3.0),and to systematically summarize the specific medication rules and treatment concepts of Professor Xie Jingri’s combined use of tonifying and reducing methods to treat this disease.Method:Collect and organize the clinical cases of patients with chronic atrophic gastritis with intestinal metaplasia treated by Professor Xie Jingri from September 2016 to September 2022 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine.According to the established case inclusion criteria,the first visit case information of 15 3 patients with chronic atrophic gastritis with intestinal metaplasia who met the requirements were entered into the management system of the"Traditional Chinese Medicine Inheritance Calculation Platform System(V3.0)" to form corresponding medical case information.The platform was used to calculate and analyze the data mining results.Result:1.Basic information of medical cases:Among 15 3 cases,there were 83 females and 70 males,with a male-to-female ratio of about 1:1.19;the age of onset was mainly concentrated between 41-70 years old.2.Frequency statistics of symptoms:A total of 93 clinical symptoms were collected from patients with chronic atrophic gastritis accompanied by intestinal metaplasia.According to the frequency of symptoms,the top 10 symptoms were:epigastric discomfort,stomach pain,poor sleep,acid reflux,heartburn,dry mouth,bitter taste in mouth,fatigue,loose stools,poor appetite;statistical results of syndrome types:liver-stomach qi stagnation syndrome was the most common.3.Frequency statistics of drugs:Among the 15 3 cases,a total of 121 Chinese medicines were involved,and the top 17 Chinese medicines in terms of frequency of use were:fried white atractylodes rhizome,bupleurum root,fried radix polygoni multifl ori,halved dendrobium,snake tongue grass,calcined sepi ell a,dried tangerine peel,perilla seed,cardamom,magnolia bark,aconite,citrus peel,Buddha’s hand fruit,chicken gizzard-skin,grass cardamom,calcined oyster shell,and immature bitter orange.The classification of drugs showed that qi-regulating drugs were dominant;among the four qi and five flavors,warm,cold,and neutral drugs accounted for 97.2%;bitter,spicy,and sweet drugs were the most frequently used among the five flavors,accounting for 83.5%;and among the four meridians,the spleen,lung,liver,and stomach meridians were the main ones,accounting for 70.4%.4.Analysis of prescription rules:11 core drugs and 45 combinations of core drugs were obtained,and 3 core prescriptions were formed.Conclusion:1.Professor Xie Jingri believes that the core pathogenesis of patients with chronic atrophic gastritis accompanied by intestinal epithelial metaplasia is liver depression and spleen deficiency,and stasis toxin accumulation.2.Professor Xie Jingri’s treatment of chronic atrophic gastritis accompanied by intestinal epithelial metaplasia focuses on the use of cold and warm medicines,spicy opening,and bitter descending.Commonly used drugs include fried white atractylodes,bupleurum,fried shenqu,half lotus,white flower snake tongue grass,calcined sepiella,tangerine peel,perilla seed,cardamom,houpu,wuyao,xiangyuan,fo shou,chicken inner gold,grass cardamom,calcined walingzi,and zhishi.3.Professor Xie Jingri’s treatment of chronic atrophic gastritis accompanied by intestinal epithelial metaplasia follows the overall treatment concept of "consumption and supplementation method" and advocates the treatment principles of "regulating the liver and relieving depression,regulating qi and eliminating stagnation,strengthening the spleen and eliminating dampness,inhibiting acid and promoting bowel movement,clearing heat and detoxifying,promoting blood circulation and removing blood stasis,nourishing qi and strengthening the spleen,nourishing yin and nourishing the stomach".