| Objective:To observe the effect and safety of Chinese medicine Muniziqi granules in patients with perimenopausal syndrome.Methods:From January 2022 to August 2022 the gynecological department of Xinjiang Medical University’s First Affiliated Hospital welcomed 68 individuals with perimenopausal syndrome who were prospectively enrolled and then randomly split two groups.The control group(34 cases)received diet adjustment,proper exercise and sunshine.On the basis of control group,treatment group(34 cases)was given medicine Muniziqi granules 1 bag/time,2 times/day for 2months.Kupperman score,perimenopausal quality of life score and adverse events were recorded in each group to evaluate the effect and safety of the drug.Results:1.There was no distinct difference in age,medical history and BMI compared between the two groups(P>0.05).2.Before treatment,there was no distinct difference in Kupperman score and quality of life score between groups(P>0.05);3.Kupperman score and quality of life score were significantly lower in the treatment group after 2 months of treatment(P<0.05),Kupperman score and quality of life score of control group had no distinct changes compared with before(P>0.05),and there were significant differences between the two groups(P<0.05);4.The total effective rate of Kupperman score in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05);5.No adverse reactions such as breast tenderness,dizziness,vaginal bleeding and gastrointestinal discomfort occurred in the two groups after treatment.Conclusion:Traditional Chinese medicine Muniziqi granules can effectively improve the symptoms of patients with perimenopausal syndrome and improve patients’ quality of life,and there is no obvious adverse drug reaction,it is worth to be popularized in clinical use. |
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