| Objective:To explore the clinical features of atypical pathogen infection in children’s acute respiratory tract,and provide a basis for the prevention and control diagnosis and treatment of atypical pathogen infections in the Urumqi area.Methods:This study was performed on 1189 children hospitalized between September 2021 and September 2022,and the duration of illness was within 72 hours of onset.Specimens were collected at the time of consultation.The serological Ig M antibody test was used to detect antibodies to three atypical respiratory pathogens,including Mycoplasma pneumonia(MP),Chlamydia pneumonia(CP)and Legionella pneumophila(LP),in 1189samples.The statistical software SPSS26.0 was used to process the data and compare the data in terms of gender,age,seasons,and site of infection,etc.Count data were expressed as number of cases or percentage,and theχ~2test was performed to identify the relationships between each groups,and the difference was considered statistically significant at P<0.05.Results:Overall pathogen detection rate:1189 pediatric patients with clinically-confirmed ARI were enrolled and 379 specimens were positive(detection rate:31.03%);Relationship between the detection rate of pathogens and gender:160 males and 209 females out of 379 positive results.The detection rate of pathogens in men and women is 25.80%and 36.73%.There was a statistically significant difference in pathogen detection rates between men and women(P<0.001);Relationship between pathogen detection rate and age:spring:1-3 years old(37.50%),3-6 years old(29.27%),6month-1year old(17.24%),6-14 years old(18.97%),and no significant differences were observed(P>0.05).Summer:the overall detection rate of pathogens was significantly higher in6month-1 year old group(36.36%)than in 1-3 year-old group(33.78%),3-6 year-old group(32.82%)and year-old group(32.79%),with a statistically significant difference(P<0.05).autumn:6-14 yyear-old group(40.00%),1-3 year-old group(42.42%),year-old group(33.33%),and 6month-1 year-old group(12.50%),with no statistically significant difference(P>0.05).In winter:the overall detection rate of the three aytpical pathogens was significantly higher in 3-6 year-old group(35.29%)than 6 months-l year-old group(28.95%),l-3 year-old group(24.62%)and 6-14 year-old group(26.98%),with statistically significant differences(P<0.05);The relationship between the detection rate of three aytpical pathogens and seasons:the overall detection rate of the three atypical pathogens in autumn(35.29%)was significantly higher than that in summer(24.62%),winter(26.98%)and spring(28.95%),and the detection rate of three aytpical pathogens were significantly associated with seasons(P<0.001);The relationship between the detection rate of three aytpical pathogens and the site of respiratory tract infection:the overall detection rate of the three atypical pathogens in the upper respiratory tract infection group was 28.54%,and the detection rate of pathogens in the lower respiratory tract infection group was 32.28%,which was not statistically significant(P>0.05);The overall detection rate was MP(19.18%),LP(17.66%)and CP(7.82%)in descending order;Mixed infections with multiple pathogens:88 cases of co-infection with two pathogens were detected,accounting for 23.85%of the positive cases,and 37 cases of mixed infections with three pathogens,accounting for 10.03%of the positive cases.Conclusion:The overall detection rate of three common atypical pathogens,including MP,CP and LP,in children clinical confirmed with ARI was correlated with gender,age and seasons.The total detection rate of the three atypical respiratory pathogens in children with acute respiratory tract infection during the survey period was31.03%,among which the detection rate of Mycoplasma pneumoniae was higher than other two pathogens,and the total detection rate of female group was higher than male group,and what could be concluded was the three atypical respiratory pathogens were commonly found in 3-6 year old children with ARI,and the detection rate of the three atypical pathogens in children with ARI was the highest in autumn;The detection rate of mixed infections was 10.51%,and children aged 1-3 years with acute respiratory infections were the most frequent group of mixed infections,which were mostly seen in winter and did not correlate with gender and site of infection.Mixed infections were mainly dual infections,among which Mycoplasma pneumoniae+Legionella pneumophila is the most common,and Mycoplasma pneumoniae could be considered the main atypical respiratory pathogen of mixed infections. |
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