Analysis Of The Medication Rule Of IBS-D(Liver And Spleen Deficiency) Based On The Auxiliary System Of TCM Inheritance

Objective: To collect the prescription of professor Zeng Binfang for patients with diarrhea irritable bowel syndrome(liver and spleen deficiency syndrome),and analyze the treatment pattern of "diarrhea irritable bowel syndrome" by using the TCM inheritance auxiliary system(V2.5).Method: Collected the effective medical cases of treating diarrhea irritable bowel syndrome in the outpatient department from January 2022 to March 2023,input the prescription drugs into the TCM inheritance assistance system(V2.5)platform,and carried out the research on TCM frequency,drug correlation and other indicators,thus obtaining the medication rules.Results: 1.According to the screening of inclusion criteria,78 valid cases were included and 164 prescriptions were included.2.Basic information statistics: a total of 43 male patients and 35 female patients,mostly at the age of 50 with70 people,which accounted for 57.69%.3.Frequency analysis: After frequency analysis,it can be learned that 1697 traditional Chinese medicines appeared in the 164 prescriptions recorded.Among these traditional Chinese medicines,the top ten drugs were prepared RADIX GLYCYRRHIZAE,bighead atractylodes rhizome,poria cocos,poria cocos,dried tangerine peel,the root of fangfeng,radices paeoniae alba,the rhizome of Chinese goldthread,the root of Chinese thorowax,cassia twig and fructus aurantii.In the four qi frequency ranking,Wen/warmth(715),Han/coolness(360),and Ping/flatness(305)were the top three.Among the frequency of the five tastes,Xin/pungency(721),Ku/bitterness(689)and Gan/sweetness(681)ranked the top three.In the frequency of meridians,the highest proportions belonged to the spleen meridian(1088),followed by stomach(604),lung(568),liver(527),heart(344),kidney(314),intestine(275),bile(247),bladder(182),small intestine(81),and trijiao(36).meridians.4.Rule analysis: Based on the platform and input data,the rule analysis was carried out.By analysis,it was known that there were9 core traditional Chinese medicines,namely,the root of Chinese thorowax,prepared RADIX GLYCYRRHIZAE,fructus aurantii,radices paeoniae alba,poria cocos,the rhizome of Chinese goldthread,dried tangerine peel,bighead atractylodes rhizome,and the root of fangfeng.5.Cluster analysis: the cluster analysis of the included TCM was conducted,and six new TCM combinations were obtained.The first group included fructus aurantii＿oriental wormwood＿fructus chaenomelis lagenariae＿radices saussureae＿the root of Chinese thorowax.The second group involved stir-baked MASSA FERMENTATA MEDICI-NALIS＿areca catechu＿lotus seed meat＿raphani.The third group involved plantago seed＿radices saussureae＿the root of Chinese thorowax＿the shell of areca nut.The fourth included Rhizoma Pinellinae Praeparata＿Rhizoma Dioscoreae＿the root of fangfeng＿Mangnolia officinalis.The fifth group included parasitic loranthus＿oriental wormwood＿bombyx batryticatus＿dried tangerine peel＿fructus chaenomelis lagenariae,and the sixth group included cassia twig＿oriental wormwood＿bombyx batryticatus＿dried tangerine or orange peel＿fructus chaenomelis lagenariae.Conclusion: The medical treatment of Professor Zeng Binnfang for IBS-D(liver and spleen deficiency)was dominant by drugs soothing the liver,tonifying spleen,resolving dampness,warming the kidney and inducing astringency with the focus on the use of drugs into the spleen,stomach,lung and liver meridians,which reflects the need to start from the "three managements",that is,manage the body,manage the dampness,and manage the astringent.1.Manage the body: It is to note the diet and adjust the mood.As the healthy spirit is stored inside,evil can not intervene.2.Manage the dampness: It is mainly to promote the clearness and dry the dampness,facilitate the drainage of water and dampness,with drugs to suppress the liver and support the spleen,strengthen the spleen and reduce dampness.3.Manage the astringent: It is to achieve the effect of converge liver Yin,and relieve diarrhea with astringents by drugs of convergence and astringent.It proceeds from these three directions,and consider medication from light to heavy gradually.