The Clinical Study On The Treatment Of Systemic Lypus Erythematosus With Yin Deficiency And Internal Heat By Nourishing Yin And Reducing Fire Method And Hormone

Objective:This study uses the method of nourishing yin and reducing fire to treat Systemic Lupus Erythematosus(SLE)with yin deficiency and internal heat.By observing the changes in traditional Chinese medicine syndrome scores,laboratory indicators,and clinical efficacy indicators before and after treatment,we explore the therapeutic effect,toxicity reduction,efficiency enhancement,and safety of this therapy on patients with SLE with yin deficiency and internal heat.Methods:This study selected 70 patients who met the diagnostic criteria for yin deficiency and internal heat type SLE,and randomly divided them into a treatment group of 35 cases and a control group of 35 cases.The control group was given oral prednisone acetate tablets and hydroxychloroquine sulfate tablets(Fenle).The treatment group was given oral prednisone acetate tablets and the method of nourishing yin and reducing fire(self formulated formula),with a treatment period of 8 weeks.Observe and record the traditional Chinese medicine syndrome scores,SLEDAI scores,ESR,CRP,complement C3,complement C4,WBC,PLT,24-hour Pro indicators,hormone withdrawal levels of patients before and after treatment,and record the adverse reactions during treatment.Statistical analysis was conducted on the data using SPSS 25.0 software to evaluate the therapeutic effects,toxicity reduction and drug safety of the two treatment regimens.Results:After 8 weeks of treatment,one of the 70 patients in the treatment group and one in the control group fell off,respectively.In terms of improving disease efficacy,the total effective rate of the treatment group reached88.24%,while the total effective rate of the control group was 70.59%,P<0.05,indicating that the treatment group has more advantages in disease efficacy.In terms of improving the efficacy of traditional Chinese medicine syndrome and reducing the total score of traditional Chinese medicine syndrome,the intra group comparison before and after treatment and the inter group comparison after treatment were both P<0.05,indicating that both groups were effective and the treatment group had more advantages than the control group.In terms of reducing individual points of traditional Chinese medicine syndromes,low fever,facial or hand redness,joint muscle swelling and pain,hair loss,five heart restlessness,dry mouth and sore throat,hot flashes and night sweats,and waist and knee soreness and weakness were compared before and after treatment within the group and between the groups,with P<0.05.Both groups were effective and the treatment group was better than the control group.In terms of improving laboratory indicators,the ESR,CRP,C3,C4,and WBC of the two groups were compared before and after treatment within the group and between the groups after treatment,with P<0.05.Both groups were effective and the treatment group was better than the control group;The comparison before and after the PLT and 24 h Pro groups showed P<0.05,indicating that both groups were effective,but there was no statistically significant difference between the two groups(P>0.05),indicating that both groups were effective and had comparable treatment effects.In terms of reducing SLEDAI: The intra group comparison before and after treatment and the inter group comparison after treatment,P<0.05,showed that the treatment group was superior to the control group.In terms of hormone withdrawal,the intra group comparison before and after treatment and the inter group comparison after treatment were both P<0.05,indicating that both groups were effective and the treatment group was superior to the control group.Conclusion:The combination of nourishing yin and reducing fire method(self formulated formula)and GC therapy for SLE of yin deficiency and internal heat type has significant improvement in disease efficacy,traditional Chinese medicine syndrome efficacy,traditional Chinese medicine syndrome score,SLEDAI score,laboratory indicators,hormone withdrawal,and other aspects.Its clinical efficacy is better than that of HCQ combined with GC,and it is safe in clinical application and has high promotion value.