Clinical Efficacy Of Modified Taohong Siwu Decoction In Treating Patients With ASO Blood Stasis Blocking Collaterals

Objective:The object of this study was to evaluate the clinical efficacy and safety of modified Taohong Siwu decoction in treating ASO(blood stasis blocking collaterals)patients.We aimed to provide a traditional Chinese medicine treatment option for this population and to contribute more references,evidences and new insights for traditional Chinese medicine treatment of ASO(blood stasis blocking collaterals).Methods:The treatment group received modified Taohong Siwu decoction combined with pentoxifylline sustained release tablets,while the control group received only pentoxifylline sustained release tablets.Both groups were treated for 28 days.We recorded and compared the traditional Chinese medicine symptom scores,clinical efficacy,ankle-brachial index(ABI),lower limb infrared thermography temperature,blood lipid and fibrinogen(FIB)levels of the two groups before and after treatment as evaluation indicators to analyze the differences in treatment effect and intervention effect.Results:1.There were 22 cases in both the treatment group and the control group for statistical analysis.During the study period,no exacerbation of symptoms or other obvious adverse reactions occurred in either group.Statistical analysis showed that there were no significant differences between the two groups in terms of baseline characteristics,symptom scores,lower limb infrared thermography temperature,ABI,blood lipid levels and FIB before treatment(P>0.05).2.After 28 days of intervention,the observation indicators of symptom scores,lower limb infrared thermography temperature,ABI and FIB were compared within and between groups.Both groups showed significant improvements in symptom scores,lower limb infrared thermography temperature,ABI and FIB levels after treatment compared with before treatment(P<0.05).The treatment group had significantly better improvements in symptom scores,lower limb infrared thermography temperature,ABI and FIB levels than the control group(P<0.05).3.There were no significant differences in blood lipid levels between before and after treatment in the control group(P>0.05),while there were significant differences in blood lipid levels between before and after treatment in the treatment group(P<0.05).4.In terms of clinical efficacy,the total effective rate was 95.5% in the treatment group and 86.4% in the control group;the cure rate was 59.1% in the treatment group and 27.3% in the control group.The differences were statistically significant(P<0.05).Conclusion:1.Modified Taohong Siwu decoction can significantly improve the outcome indicators such as ABI,lower limb temperature,blood lipid level,and FIB in patients with ASO due to blood stasis blocking collaterals,and the effect is better than that of pentoxifylline sustained release tablets alone.2.The clinical application of modified Taohong Siwu decoction is safe and worthy of promotion.