Analysis Of The Correlation Between Inflammatory Response And The Onset And Prognosis Of Sudden Deafness

Objective: To investigate whether there is any correlation between inflammatory response and the onset of sudden deafness,and to explore the associated risk factors affecting the prognosis of sudden deafness,as well as to assess the value of inflammatory response-related indicators in the diagnosis and prognosis of sudden deafness.Methods:In this study,patients with sudden deafness in our ENT department from October 2020 to October 2022 were selected as the case group and patients with nasal septal deviation as the control group,and case enrollment and treatment were in accordance with the guidelines for the diagnosis and treatment of sudden deafness(2015).Patients’ peripheral blood was taken upon admission and tested for inflammatory response index.Pure-tone hearing tests were performed,and the time from onset to consultation,main symptoms,concomitant symptoms and regression were also recorded to compare whether there was any statistical difference between the inflammatory response indexes of the two groups,hearing curve,inflammatory response index,concomitant symptoms(tinnitus,deafness,vertigo),comorbidities(cardiovascular disease,diabetes,cervical spine disease)and prognosis of patients with sudden deafness were investigated.Results:(1)Comparison of inflammatory response indexes between case and control groups yielded white blood cell count,neutrophil count,NLR,and PLR,with statistically significant differences(P < 0.05),while the differences in lymphocyte count,platelet count,and mean platelet volume(MPV)were not statistically significant(P > 0.05).(2)Leukocytes,neutrophils,lymphocytes,NLR,PLR,and MPV were not significantly correlated with different types of sudden deafness(P > 0.05).(3)Univariate and multifactorial analyses showed that time from onset to consultation and NLR were correlated with the prognosis of patients with sudden deafness(P < 0.05),and their NLR levels were the main independent influencing factors;gender,age,causative factors,hearing curve,concomitant symptoms(tinnitus,deafness,vertigo),and comorbidities(cardiovascular disease,diabetes mellitus,cervical spine disease)were not significantly There was no significant correlation between the prognosis of patients with sudden deafness(P > 0.05).Conclusion: The presence of abnormal peripheral blood leukocytes,neutrophil count,NLR,PLR and other inflammatory response indicators in patients with sudden deafness suggests a correlation between inflammatory response and the onset of sudden deafness.The prognosis of sudden deafness was correlated with the time from onset to consultation and the level of NLR,among which the level of NLR had a predictive effect on the prognosis of sudden deafness.