Association Of Juxtcortical Lesions With Cognitive Impairment In Patients With Relapsing-remitting Multiple Sclerosis

Objective: This time,the number and volume of juxtcortical lesions were obtained by using the automated MRI brain volume system,mainly to investigate the role of juxt cortical lesions and cognitive impairment in MS patients,and whether cognitive impairment can be identified early and intervened to improve the quality of life of patients.Materials and methods: From December 2020 to December 2022,patients who were treated in Xinjiang Autonomous Region People’s Hospital and clearly diagnosed with relapsed-remitting multiple sclerosis were subjected to neuropsychological evaluation(MMSE and Mo CA scales),and retrospective analysis of lesions in cranial magnetic resonance T1 and T2 FLAIR imaging was performed on the collected patients(fully automatic quantitative analysis of demyelinating lesions by automatic brain volume system,and analysis reports in pdf format were given).to properly assess the relationship between juxtcortical lesions and cognition.Results: Among the 30 patients with MS enrolled,19 had cognitive impairment,and there were significant differences in gender,EDSS,number of juxtcortical lesions,absolute volume,standardized volume and lesion load between the two groups of normal cognition and cognitive impairment groups,and correlation analysis showed that gender,EDSS,and the number,volume and lesion load of juxtcortical lesions were significantly correlated with Mo CA.Conclusion: Patients in the cognitive impairment group showed higher EDSS,number of juxtcortical lesions,absolute volume,standardized volume,and lesion load,while there were no significant differences in gender,age,course of disease,and cultural degree between the two groups.Studies suggest that a longer course of disease,male sex,higher physical disability(EDSS),and more number and volume of nearcortical lesions are associated with the severity of cognitive impairment.