Clinical Study On The Efficacy Of Micro-balloon Compression In The Treatment Of Primary Trigeminal Neuralgia And Its Impact On Inflammatory Factors

Objective: To observe the efficacy of percutaneous microballoon compression(PMC)and radiofrequency thermocoagulation(RFT)in the treatment of trigeminal neuralgia and their effects on pain transmitters and inflammatory factors in the blood of patients.Methods: From March 2021 to Feburary 2022,106 patients with trigeminal neuralgia who had no effect on oral carbamazepine were enrolled into the study.According to the treatment methods,the patients were randomly divided into the observation group receiving microcapsule compression(n=54)and the control group receiving radiofrequency thermocoagulation(n=52).Enzyme linked immunosorbent assay was used to detect substance P,5-hydroxytryptamine(5-HT),calcitonin gene related peptide(CGRP),and interleukin-1β(IL-1 β)、 Tumor necrosis factor-α(TNF-α)And interleukin-6(IL-6)levels in the blood of patients before and on the 3rd day after surgery;Before and on the 3rd day and 1,3 months after surgery,the degree of pain was assessed using the Digital Pain Intensity Scale(NRS),the quality of life was assessed using the Pittsburgh Sleep Quality Index(PSQI),and the effect was evaluated using the modified Macnab standard score;All patients were followed up for 3 months to observe the incidence of complications such as facial numbness,masseter muscle weakness,lip herpes,hearing,and eye symptoms,and to record the recurrence rate within 1 year.Results: The NRS and PSQI scores of both groups of patients decreased at each time point after surgery,and the differences were statistically significant(P < 0.05).The PMC group had better scores than the RFT group(P < 0.05).The levels of SP,5-HT,CGRP,IL-1β,TNF-α,and IL-6 in the blood of both groups of patients decreased after surgery,with the PMC group having lower levels than the RFT group(P < 0.05).The PMC group had more facial numbness,lip herpes,and eye symptoms after surgery than the RFT group.According to the comparison of prognostic indicators,the gender distribution and incidence of postoperative complications did not differ significantly between the recurrence and non-recurrence groups.The △IL-1β,△TNF-α,and △IL-6 levels in the recurrence group were significantly lower than those in the non-recurrence group(P < 0.05),with statistical significance.Conclusion: PMC and RFT are effective methods for treating primary trigeminal neuralgia.Compared with RFT,PMC can more effectively inhibit the inflammatory response of patients with primary trigeminal neuralgia,relieve pain,and improve sleep quality,but the incidence of facial numbness,hearing loss,and eye discomfort after surgery is higher.The more inflammatory factor levels decrease in patients with primary trigeminal neuralgia after surgery,it may reflect a lower postoperative recurrence rate.