Correlation Between Metabolic Healthy Obesity And Depressive Symptoms In Rural Areas Of Liaoning Province

Objective: The health correlation of metabolic health related obesity(MHO),especially with depressive symptoms,is still unclear.Therefore,we divided subjects into four groups based on the definition of metabolic health to study the correlation between patients with this phenotype and depressive symptoms.Methods: The data of this study are from the cross-sectional data of the rural cardiovascular health research population in Northeast China.A total of 11956 permanent residents aged 35 and older were included in this population.After excluding those with missing relevant data,11423 respondents were finally included in this study.According to the definition of body mass index(BMI)and metabolic health,they were divided into metabolic healthy non-obese group(MHNO),metabolic healthy obesity group,metabolic unhealthy non-obese group(MUNO)and metabolic unhealthy obesity group(MUO).We used patient health Questionnaire-9(PHQ-9)to evaluate the degree of depressive symptoms of the respondents,and according to the scale score,the subjects were divided into no depressive symptoms Mild depressive symptoms and moderate or above depressive symptoms.Analyze and compare the basic characteristics of different phenotype populations,as well as the current situation of depressive symptoms in rural areas of Liaoning Province;The characteristics of different depression states were compared,and Spearman correlation analysis was used to study the correlation between depression and baseline characteristics.Logistic regression was used to analyze the risk of depressive symptoms in the four groups.Results: The overall detection rate of depressive symptoms in rural areas of Liaoning Province was 6.0%(1.6% males and 4.4% females).The mhno group,mho group,muno group and MUO group accounted for 43.9%,17.6%,11.2% and 27.3% respectively.The prevalence of obesity was 44.9%,of which 39.2% were classified as metabolic health.According to the analysis of depressive symptoms in the four groups,the detection rate of mild,moderate and above depressive symptoms in mho group was lower than that in the other three groups,while the detection rate of mild,moderate and above depressive symptoms in muno group was the highest.In the metabolically healthy population,the detection rate of depressive symptoms in obese people was lower than that in non-obese people;In the obese population,the detection rate of depressive symptoms in the metabolically unhealthy population was higher than that in the metabolically healthy population.The detection rate of depressive symptoms was higher in women,older people,lower education level,lower income,and low physical activity.In the correlation study between phenotypes and depressive symptoms,no correlation between MHO phenotypes and depressive symptoms was found in the overall and gender analysis(P > 0.05).In the population older than or equal to 50 years old,the risk of depressive symptoms was increased in the MUNO group compared with the MHNO group after multivariate adjustment(or = 1.323,95% CI: 1.020-1.718);The risk of depressive symptoms in MHO phenotype was reduced(or = 0.670,95% CI: 0.473-0.950).Conclusion: This study shows that in the population aged ≥ 50 years,compared with the metabolically healthy non-obese population,the metabolically healthy obese people have a lower risk of depressive symptoms,while the metabolically unhealthy non-obese people have a higher risk of depressive symptoms.