| Objective:Through preoperative evaluation of AFP,tumor size,ANR(alkaline phosphatase to neutrophil ratio),and other clinical data in patients with hepatocellular carcinoma,a model was constructed using these data to predict the presence of MVI in patients with hepatocellular carcinoma.Methods:This study collected clinical data of patients with hepatocellular carcinoma who received surgical treatment from the First Affiliated Hospital of China Medical University from November 1,2019 to December 31,2021.The patients were divided into MVI negative group and MVI positive group according to the pathological diagnosis after operation.The relationship between AFP,ANR,tumor size and other clinical data was evaluated by single factor analysis,subject working characteristic(ROC)curve,minimum absolute contraction and selection operator(LASSO)analysis and logical analysis,and the model was constructed to make reasonable inference on whether there was MVI in patients diagnosed as hepatocellular carcinoma before operation.Results:The critical value of the area under the ROC curve to determine the ANR is24.71.Single factor analysis showed that MVI positive results and age(χ~2=6.772,p=0.009),tumor size(χ~2=24.148,p=0.001)、AFP(χ~2=11.627,p=0.001)、ALP(χ~2=10.072,p=0.002)、GGT(χ~2=14.839,p=0.001),albumin(χ~2=4.488,p=0.034),fibrinogen(χ~2=9.465,p=0.03)、ANR(χ~2=6.97,p=0.008).LASSO analysis showed that the risk factors of MVI were sex,age,tumor size,ALP,albumin,ALR(ALP/lymphocyte)and NLR(fibrinogen/lymphocyte).Multiple logistic regression analysis showed that age<53.5years(OR0.489,p=0.012),AFP≥200μg/m L(OR1.903,p=0.02),tumor size≥6.05cm(OR1.895,p=0.044),ANR≥24.71(OR2.041,p=0.035).Conclusion:Preoperative ANR,tumor size,AFP and age are reliable indicators to predict the presence of MVI in patients with hepatocellular carcinoma,which is of great significance for these patients to formulate reasonable surgical and other treatment plans before surgery. |
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