Exploration Of Clinical Characteristics And TCM Pathological Mechanisms Of Dampness-Constipation Based On Syndrome-Element Differentiation

ObjectivesConstipation is a common clinical disease.Dampness-constipation is a special type of constipation caused by dampness,which is often mentioned in ancient books and is also common in clinical practice.However,there is no specific description of Dampness-constipation in current textbooks,guides and consensus.At present,although the diagnosis and treatment of constipation in the academic circle is becoming more and more complete,it is mostly based on the experience of scholars and clinical investigation,lack of unified understanding.Therefore,based on syndrome-element differentiation and statistical method,this subject objectively discusses the pathological mechanism of Dampness-constipation,which can provide reference for clinical differentiation and treatment of dampness and mystics in TCM.MethodsThe study selected 60 who were admitted to the Second Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine and The 900 th Hospital of the Joint Service Support Force of the People’s Liberation Army of China from January 2022 to January 2023.Basic information such as general data,symptoms and signs were collected through face-to-face questionnaires.Collect general information,symptoms and signs and other basic information in the form of a face-to-face questionnaire,and fill in the information collection form for the four diagnoses.The syndrome element differentiation system(TCM health status identification and consultation system)was used to process the information and obtain the distribution of Dampness-constipation syndrome elements.Using the method of syndrome-element differentiation and statistical analysis,the relationship between pathogenic syndrome elements and pathogenic location syndrome elements of Dampness-constipation was obtained,and the clinical characteristics and pathological mechanism of Dampness-constipation were discussed.Results1.The male to female ratio of the subjects in this study was 1:1.40,and the age ranged from 75 years old to 19 years old;Young people accounted for 35.00%,the middle-aged accounted for 31.67% and the elderly accounted for 33.34%.2.The mean BMI was 23.67±3.37,with a minimum value of 17.4 and a maximum value of 33.3.The low body weight group accounted for 5%,the normal body weight group accounted for 56.67%;Hyperrecombination accounted for 31.67%;The obese group accounted for 6.67%.There was no significant difference in BMI between male and female groups(P > 0.05).3.16.67% were fond of eating fat,sweet and thick taste,3.33% were fond of spicy food;16.67% were addicted to tobacco,5.00% were addicted to alcohol,and 13.33% were addicted to alcohol and tobacco.4.There are 12 kinds of syndrome elements in total,mainly spleen,large intestine,stomach and liver,accounting for 82.90%,and also involving small intestine,kidney,gallbladder,heart spirit,uterus,exterior,heart and lung.There were 14 kinds of pathogenic syndromic elements,and the solid syndromic elements were mainly dampness,qi stagnation,phlegm and heat,accounting for 48.39%,and also involved blood stasis,food accumulation,cold,Yang hyperactivity and summerheat.Deficiency syndrome elements mainly include qi deficiency,Yang deficiency,Yin deficiency and blood deficiency,accounting for 40.37%.5.Through correlation analysis,it is concluded that: The stomach(r=0.313),liver(ρ=0.314),dampness(r=0.613),qi stagnation(r=0.402),phlegm(ρ=0.364),qi deficiency(ρ=0.729),Yang deficiency(ρ=0.678)were significantly positively correlated with spleen.Dampness(ρ=0.296),qi stagnation(ρ=0.371),heat(ρ=0.443),small intestine(ρ=0.574)were significantly positively correlated with large intestine.The spleen(r=0.613),stomach(ρ=0.326),liver(ρ=0.275),phlegm(ρ=0.639),qi stagnation(r=0.479),heat(ρ=0.305),small intestine(ρ=0.420)were significantly positively correlated with dampness.The spleen(r=0.402),large intestine(ρ=0.371),stomach(ρ=0.307),liver(ρ=0.696),dampness(r=0.597),phlegm(ρ=0.450),small intestine(ρ=0.423)were significantly positively correlated with qi stagnation.(P < 0.05)Conclusions1.The syndrome elements of location of disease of Dampness-constipation are mainly spleen,large intestine,stomach and liver,and others include small intestine,kidney,gallbladder,heart,cell palace,surface,heart and lung.2.The number of excess syndrome elements is more than the number of deficiency syndrome elements.The main solid syndrome elements are dampness,others are qi stagnation,phlegm,heat,blood stasis,food accumulation,cold,Yang hyperactivity,summerheat.Deficiency syndrome elements include qi deficiency,Yang deficiency,Yin deficiency,blood deficiency and fluid depletion.3.Syndrome elements of the stomach,liver,dampness,qi stagnation,phlegm,qi deficiency and Yang deficiency are related to the spleen.Syndrome elements dampness,qi stagnation,heat,small intestine are related to intestine.Spleen,stomach,liver,phlegm,qi stagnation,heat,small intestine are related to dampness.Spleen,large intestine,stomach,liver,dampness,phlegm,small intestine are related to qi stagnation.4.The pathological mechanisms of dampness-constipation is the deficiency of Qi and Yang of the spleen,which leads to endogenous dampness turbidity and obstruction of the large intestine,leading to large intestine qi stagnation and dereliction of duty in conduction.The location of disease is mainly includes spleen,large intestine,can involve the stomach,liver,small intestine.The nature of disease is mainly includes dampness and qi stagnation,often combined with heat and phlegm.