Distribution Characteristics And Related Factors Of TCM Syndrome Of Chronic Gastritis With Bile Reflux

Research objectives:1.To explore the distribution characteristics of TCM syndromes in patients with chronic gastritis accompanied by bile reflux;2.To explore the relationship between TCM syndromes of patients with chronic gastritis accompanied by bile reflux,general information and related auxiliary examination,so as to provide certain basis for clinical differentiation,prevention and treatment.Research methods:1.In this cross-sectional study,262 patients with chronic gastritis accompanied by bile reflux were enrolled in the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine from November 2021 to November 2022.General data,information of four traditional Chinese medicine examinations and related auxiliary examination results were collected.2.Data sorting and statistics: Excel data table of the four diagnoses of TCM was established,statistical software SPSS26.0 was used for systematic cluster analysis of the four diagnoses of patients,and distribution characteristics of TCM syndrome in patients with chronic gastritis accompanied by bile reflux were summarized.Chi-square test and nonparametric test were used to analyze the relationship between TCM syndrome and general data(gender,age,course of disease,lifestyle,etc.)and auxiliary examination results of patients with chronic gastritis accompanied by bile reflux.Research results:1.General information: Among the 262 patients,the male to female ratio was 1:2.13,and the average age was 47.76±15.83 years old;16.0% combined with biliary diseases;23.7% had a history of cholecystectomy.2.Distribution characteristics of TCM syndromes: the top 10 symptoms and signs in the frequency list of patients were bitter mouth,dry mouth,nausea and vomiting,fatigue and weakness,acid reflux,stuffy stomach,aggravation after meals,dull stomachache,poor sleep,and lack of sleep.The most common tongue and pulse patterns were light red tongue,thin white coating and fine pulse string.The cluster analysis classified five syndromic types: spleen and stomach weakness syndrome(31.2%)> liver and stomach qi stagnation syndrome(24.8%)> gallbladder heat attack stomach syndrome(22.1%)> deficiency of stomach Yin syndrome(11.1%)> spleen and stomach damp-heat syndrome(10.7%).3.The relationship between the syndrome of chronic gastritis accompanied by bile reflux and gender,age,course of disease and lifestyle: there were statistically significant differences between liver-stomach Qi-stagnation syndrome and spleen-stomach damp-heat syndrome(P<0.05).The liver-stomach Qi-stagnation syndrome was mainly female,while the spleen-stomach damp-heat syndrome was mainly male.There was no statistical significance in age difference among TCM syndrome groups(P>0.05).There was statistical significance in the course of liver and stomach qi stagnation syndrome and spleen and stomach weakness syndrome(P<0.05).The course of liver and stomach qi stagnation syndrome was ≤0.5 years,while the course of spleen and stomach weakness syndrome was 1-2 years.There was statistical significance in the difference between the syndrome of bile heat attacking stomach and the syndrome of deficiency of stomach Yin(P<0.05).The syndrome of bile heat attacking stomach mainly consisted of drinking alcohol,while the syndrome of deficiency of stomach Yin mainly consisted of unbiased addiction.The dietary habits of gallbladder heat attacking stomach syndrome,deficiency of stomach Yin syndrome and deficiency of spleen and stomach syndrome had statistical significance(P<0.05).Gallbladder heat attacking stomach syndrome tended to be spicy,while deficiency of stomach Yin syndrome and deficiency of spleen and stomach syndrome were not biased.There were statistically significant differences in the emotion expression of liver-stomach qi stagnation syndrome,gallbladder heat affecting stomach syndrome and spleen and stomach weakness syndrome(P<0.05).The emotion expression of liver-stomach qi stagnation syndrome and gallbladder heat affecting stomach syndrome was mainly impatience,while the emotion expression of spleen and stomach weakness syndrome was mainly calm.The sleep status of spleen and stomach weakness syndrome and deficiency of stomach Yin syndrome was better than that of liver and stomach qi stagnation syndrome(P<0.05).4.The relationship between the syndrome of chronic gastritis accompanied by bile reflux and the manifestation of Hp and gastric mucosa: the comparison between the syndrome of bile heat affecting the stomach,the syndrome of liver and stomach qi stagnation and the syndrome of spleen and stomach weakness was statistically significant(P<0.05),and the positive rate of Hp in the syndrome of bile heat affecting the stomach was higher than negative.The degree of erythema of gastric mucosa in syndrome of deficiency of stomach Yin and spleen and stomach dampness-heat was higher than that in syndrome of spleen and stomach weakness(P<0.05).The degree of gastric mucosa erosion in syndrome of deficiency of stomach Yin and spleen and stomach dampness-heat was higher than that in syndrome of spleen and stomach weakness and liver-stomach qi stagnation(P<0.05).Conclusion:1.TCM syndromes of patients with chronic gastritis accompanied by bile reflux are mainly type 5,with distribution characteristics as follows: syndrome of spleen and stomach weakness > syndrome of liver and stomach qi stagnation > syndrome of gallbladder heat affecting stomach > syndrome of deficiency of stomach Yin > syndrome of spleen and stomach damp-heat.2.The life style of the patient,such as alcohol,tobacco,spicy and bad mood,history of biliary diseases and gastrointestinal surgery,may be the inducement factors of chronic gastritis with bile reflux.3.In this study,TCM syndrome of patients with chronic gastritis accompanied by bile reflux was related to gender,course of disease,drinking,spicy diet,sleep status,emotional expression,Hp infection rate,gastric mucosa expression and other factors.