Selection Of Bone Paralysis Combination And Tendon Soup For KOA Staging Treatment

Objective: To observe the selection of pharmacological treatment(bone paralysis combination,tendon and bone soup)for different clinical stages of KOA in order to achieve an effective plan for the precise treatment of KOA.Methods: 1.Patients from the Department of Orthopaedics and Traumatology of the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine from December2021 to December 2022 were selected,and patients with osteoarthritis of the knee who met the inclusion criteria were divided into 1)exacerbation group(Group A),2)remission group(Group B),and 3)recovery group(Group C),with 40 cases in each group,and a total of 120 cases were enrolled.Each group was then randomly divided into bone paralysis group(X group)and tendon and bone soup group(Y group)by using the random sampling grouping method in the ratio of 1:1.2.Treatment plan(1)Each group was treated with basic treatment,which included guiding patients to recognize the disease and functional exercises.(2)Drug treatment:Bone paralysis compound group(X group)was given bone paralysis compound(approval number: [Yunnan Pharmaceutical System(Z)04A01887])orally twice a day,1bottle(100 ml/bottle)each time,once in the morning and once half an hour after dinner.The muscular and bone broth group(Y group)was given oral administration of muscle-bone broth(the muscle-bone broth is derived from Qing.Chen Shiduo "Dialectic" of "Yangjian Soup"),take one dose(200ml/dose)a day,once in the morning and once half an hour after dinner.Each group was given one course of treatment for 7 days,and 4 courses of treatment for one observation period,totaling 28 days.(3)Both groups X and Y in each period were observed and compared in VAS score,WOMAC score,TCM evidence score,and SF-36 health questionnaire quality of life score at two time points before and after treatment(day 28),and the safety of the drugs was considered.Results: After treatment,the TCM symptom scores,WOMAC scores,and VAS scores decreased to different degrees(P<0.05),and the SF-36 Health Questionnaire quality of life scores increased to different degrees(P<0.05)in all groups.In group A,the effective rate of Bone Paralysis Combination was 80% and the effective rate of Tendon Bone Soup was55%;in group B,the effective rate of Bone Paralysis Combination was 75% and the effective rate of Tendon Bone Soup was 45%;in group C,the effective rate of Bone Paralysis Combination was 55% and the effective rate of Tendon Bone Soup was 85%.No safety problems were observed for both drugs(P>0.05).Conclusion: Both Bone Paralysis Combination and Tendon Soup have good clinical efficacy for patients with knee osteoarthritis.Bone Paralysis Combination was more effective in treating patients with knee osteoarthritis in the exacerbation and remission phases,while Tendon Soup was more effective in treating patients with knee osteoarthritis in the rehabilitation phase.Both had a significant impact on improving knee function and quality of life,and showed no safety concerns.