Clinical Study On The Treatment Of RIF Caused By IUA Due To Kidney Deficiency And Blood Stasis By Combining Internal And External Application Based On The Theory Of Gasification

Objective Based on the theory of gasification,the differences in clinical symptoms,uterine artery blood flow indexes and endometrial thickness before recurrent implantation failure(RIF)caused by renal deficiency and blood stasis intrauterine adhesions(IUA)were compared with internal administration combined with traditional Chinese medicine application and oral renal regulation membrane prescription.To explore the improvement of uterine receptivity in patients with renal deficiency and blood stasis IUA-induced RIF in patients with renal deficiency and blood stasis,and to provide a scientific basis for TCM internal and external coordination to promote endometrial repair and improve the endometrial microenvironment before embryo retransfer.Methods The 72 cases that met the inclusion criteria were numbered and randomly numbered,and were divided into treatment group(oral renal regulation combine traditional Chinese medicine compress treatment)and 36 cases in the control group(oral renal regulation united traditional Chinese medicine patch treatment)according to the random principle,and 3 courses of treatment.The improvements of TCM clinical symptoms,pulsation index(PI),resistance index(RI)and endometrial thickness on the 21 st day of menstruation were observed and compared between the two groups,and their efficacy and safety were evaluated by statistical analysis.Results At the end of the treatment of this study,after quality control screening,5subjects were dropped out and excluded from the experimental group and the control group,3 dropped out after being unable to adhere to the treatment,and 7 voluntarily withdrew due to personal reasons.1.Clinical symptoms of traditional Chinese medicine(1)Clinical symptoms of traditional Chinese medicine(see Appendix 4 for details):intra-group comparison: both groups can significantly improve the patient’s menstrual condition,waist and knee soreness,lower abdomen distension and pain,loss of libido,cold extremities,fatigue symptoms(P<0.05);the treatment group can also improve the frequency of urination,dull complexion(P<0.05),insomnia and forgetfulness symptoms before and after treatment(P<0.05);the control group can also significantly improve the symptoms of dizziness and tinnitus(P<0.05),insomnia and forgetfulness,urinary frequency,There was no significant difference between the symptoms of dullness before and after treatment(P>0.05).Comparison between groups: after treatment,there were statistical differences between the two groups(P1>0.05)in menstrual conditions,waist and knee soreness,lower abdomen distention,decreased libido,frequent urination,cold extremities,fatigue,and dull complexion between the two groups,and the menstrual conditions,waist and knee soreness,lower abdomen distention,decreased libido,frequent urination,cold extremities,fatigue,and dull complexion in the treatment group were better than those in the control group(P1>0.05);after treatment,there was no significant difference between the symptoms of dizziness,tinnitus,insomnia and forgetfulness between the two groups(P1>0.05).(2)Total points of clinical symptoms of traditional Chinese medicine:the total points of clinical symptoms of traditional Chinese medicine in the two groups after treatment were significantly lower than before(P<0.01),and the reduction in the treatment group was better than that of the control group(P<0.01).(3)The overall efficacy of traditional Chinese medicine:the total effective rate of the treatment group was 80.65%,and the pre-manifestation rate was 45.16%;The control group had an effective rate of 71.00% and a pre-evident rate of 16.13%,and the treatment group was better than that of the control group(P<0.05).2.Endometrial blood flow(1)Uterine artery PI: compared before and after treatment,both groups could effectively reduce the window period uterine artery PI value(P<0.01);after treatment,the treatment group had a more obvious decrease in PI than the control group(P<0.05).(2)Uterine artery RI: compared before and after treatment,both groups could effectively reduce the window period uterine artery RI value(P<0.01);after treatment,the treatment group had a more obvious reduction in RI than the control group(P<0.05).3.Endometrial thicknessCompared with the two groups before and after treatment,the endometrial thickness in the window period(P<0.01)could be increased in both groups,and the endometrial thickness in the treatment group was better than that in the control group(P<0.05)after treatment.4.Security indicatorsDuring the study,the safety indicators of both groups were normal,and there were no adverse effects.Conclusion1.Based on Gasification theory;Oral Tiaoshen Xuanluo changmo Decoction combined with traditional Chinese medicine compress for improving renal deficiency and blood stasis type Intrauterine adhesions;Menstrual conditions of patients with recurrent implantation failure,soreness of waist and knees,abdominal distension and pain,loss of libido,frequency of urination,cold extremities,fatigue,dull complexion are effective,and the efficacy is better than that of simple oral kidney regulation and membrane smoothing.2.Oral renal regulation and oral renal regulation membrane combination with traditional Chinese medicine dressing can reduce the PI and RI values of RIF patients with renal deficiency and blood stasis type IUA,and increase the thickness of the endometrium on the 21st day of menstruation;Moreover,oral kidney regulation Xuanluo Chang membrane combination with traditional Chinese medicine compress has better efficacy than oral traditional Chinese medicine alone.3.Based on the theory of gasification,the combination of internal and external medicine in traditional Chinese medicine is conducive to improving endometrial blood perfusion before retransplantation of patients with RIF due to IUA retransfer,increasing endometrial receptivity.