Clinical Observation Of Jinghe Yangxinshu In The Treatment Of Chronic Heart Failure With Qi Deficiency,Blood Stasis And Water Stop Syndrome

Objective:To evaluate the clinical efficacy and safety of Jinghe Yangxinshu in treating CHF patients with Qi deficiency,blood stasis and water retention,and to preliminarily discuss its mechanism of action.Method:To select CHF patients in the Department of Emergency-Critical Care Medicine,Department of Cardiovascular Diseases and Specialist Outpatient Clinic of Kunming Hospital of Traditional Chinese Medicine,and 72 patients were included by referring to the inclusion and exclusion criteria in this study.The 72 patients were randomly divided into treatment group and control group,with 36 patients in each group.The control group was given conventional western medical treatment,while the treatment group was given Jinghe Yangxinshu and conventional Western medical treatment.Both sessions were 28 days.The TCM evidence score,MLHFQ scale,NYHA cardiac function classification,BNP,and LVEF of the two groups before and after treatment were observed.Result:1.In this study,72 CHF patients with Qi deficiency,blood stasis and water stop syndrome were included,with 3 shedding cases and 69 effective cases.There was no statistical difference in the comparison of basic data and efficacy indexes between the two groups before treatment(P > 0.05),so they were comparable.2.TCM Syndrome Score: The treatment of both groups can significantly reduce the total TCM syndrome score and each individual TCM syndrome score(P < 0.01),and after treatment,the total score of TCM syndrome and TCM syndrome scores of Asthma,Fatigue and Spontaneous sweating in the treatment group were lower than that of the control group(P <0.05),and the treatment group was significantly lower than the control group in the single TCM syndrome score of Edema of face and limb(P <0.01),And there were no statistical difference in the single TCM syndrome score of Palpitations,Chest tightness(Chest pain),Sputum,and Abdominal distension in TCM syndrome single integral(P> 0.05).3.NYHA cardiac function classification: In the treatment group,the total effective rate of NYHA cardiac function classification was 85.3%,which was significantly higher better than the total effective rate of NYHA cardiac function classification in the control group of 60%(P < 0.01).4.MLHFQ scale scores: The MLHFQ scale ratings were markedly lower than before treatment in two groups after treatment(P < 0.01),and the decrease in the treatment group was higher than that in the control group after treatment(P < 0.05).5.LVEF: The LVEF was considerably higher than before treatment in two groups(P<0.01),and the treatment effect in the treatment group was also higher than that for the control group(P<0.05).6.BNP: After treatment,BNP values in both groups were found to be substantially lower than those before treatment(P < 0.01),and in the treatment group,BNP values showed lower than those of the control group after treatment(P < 0.05).Conclusion:1.The symptoms of CHF patients with Qi deficiency,blood stasis and water stop syndrome can be relieved by “Jinghe Yangxinshu”.2.Quality of life and cardiac function in CHF patients with Qi deficiency,blood stasis and water stop syndrome can be improved by “Jinghe Yangxinshu”.3.“Jinghe Yangxinshu” can enhance LVEF values and reduce BNP levels in CHF patients with Qi deficiency,blood stasis and water stop syndrome.4.“Jinghe Yangxinshu” has no adverse effects in CHF patients with Qi deficiency,blood stasis and water stop syndrome.