Clinical Study On Treatment Of Hypertension With Left Ventricular Hypertrophy (Yin Deficiency And Yang Hyperactivity Syndrome) With Xiaxi Sanshi Decoction

Objective: This study aims to observe the clinical efficacy and safety of Xia Xi San Shi Tang,a traditional Chinese medicine,in reducing blood pressure and improving left ventricular hypertrophy,in order to provide new clinical ideas and theoretical basis for the treatment of hypertension with left ventricular hypertrophy with traditional Chinese medicine.Methods: This study included a total of 72 patients who met the criteria and were randomly divided into an experimental group and a control group,with 36 patients in each group.The experimental group was treated with standardized Western medicine and traditional Chinese medicine Xiaxi Sanshi Tang,while the control group was only treated with standardized Western medicine for 12 weeks.The observed efficacy indicators included 24 h SBP and 24 h DBP,as well as cardiac ultrasound related indicators including IVST,LVPWT,LVMI,traditional Chinese medicine syndrome scores,scores on the Du’s hypertensive quality of life scale,serum homocysteine(Hcy)levels,and serum angiotensin II(Ang II)levels.Finally,statistical analysis was conducted on the obtained efficacy indicators to draw the final conclusion.Results: A total of 72 patients who met the criteria were included in this study,including 4 who fell out,and 68 patients who ultimately completed the study.1.Basic information: Before treatment,there was no significant difference in general information between the two groups of patients,including age,gender,height,weight,BMI,course of disease,and comorbidities(P>0.05),indicating comparability.2.24-hour ambulatory blood pressure: The total effective rate of blood pressure reduction in the experimental group was 88.2%,while the total effective rate of blood pressure reduction in the control group was 79.4%.After treatment,the 24-hour SBP and24-hour DBP in both groups decreased compared to before treatment.There was a statistical difference between the two groups after treatment(P<0.05),and the blood pressure reduction effect in the experimental group was better than that in the control group.3.Cardiac ultrasound related index: After treatment,the IVST,LVPWT,and LVMI in the experimental group decreased compared to before treatment(P<0.05),while the IVST and LVMI in the control group decreased compared to before treatment(P<0.05).There was no statistical difference before and after LVPWT treatment(P>0.05).After treatment,the experimental group was more able to reduce LVPWT indicators compared to the control group(P<0.05),and there was no difference in reducing IVST and LVMI between the two groups(P>0.05).Overall,the experimental group outperformed the control group in improving left ventricular hypertrophy.4.Traditional Chinese Medicine Syndrome Efficacy: The total effective rate of the experimental group was 82.4%,while the total effective rate of the control group was 44.1%.There was a statistical difference between the groups(P<0.05),and the experimental group was superior to the control group.5.Du’s Quality of Life Scale: After treatment,the total quality of life scores of both groups of subjects improved.Compared with the control group,the experimental group showed statistical differences in physiological status,somatization symptoms,sleep status,anxiety,depression,and hostility(P<0.01),and the experimental group was more able to improve the quality of life of patients.6.Serum Hcy and Ang II levels: Both the control group and the experimental group were able to reduce plasma Hcy and Ang II levels,with significant differences between the groups(P<0.01).The experimental group was more effective than the control group.7.Clinical safety: Both groups of subjects did not experience any safety issues or adverse reactions.Conclusion:1.Xia Xi San Shi Tang can reduce the systolic and diastolic blood pressure of patients with Yin deficiency and Yang hyperactivity type hypertension accompanied by left ventricular hypertrophy.2.Xia Xi San Shi Tang can significantly improve the traditional Chinese medicine symptoms of patients with yin deficiency and yang hyperactivity type hypertension accompanied by left ventricular hypertrophy,reduce traditional Chinese medicine syndrome scores,and improve the quality of life of patients.3.Xia Xi San Shi Tang can reduce the levels of serum Hcy and plasma Ang II in patients with Yin deficiency and Yang hyperactivity type hypertension accompanied by left ventricular hypertrophy,and has an improvement effect on left ventricular hypertrophy.