Based On Data Mining And Network Pharmacology,Explore The Rule Of Medication And Mechanism Of Action Of Traditional Chinese Medicine In The Treatment Of Coronary Heart Disease After PCI(Qi Deficiency And Blood Stasis Syndrome)

Objective: To analyze the application of traditional Chinese medicine inheritance assistance platform and network pharmacology technology to investigate the medication law and mechanism of traditional Chinese medicine in the treatment of qi deficiency and blood stasis after PCI of coronary heart disease.Methods: By collecting the databases(China Journals Full-text Database(CNKI),Wanfang Data(Wanfang Data),Weipu Database(VIP)China Biomedical Literature Database(CBM))from January 1,1980 to December 30,2021,and the modern literature on the evidence of qi deficiency and blood stasis after PCI surgery in the treatment of coronary heart disease by traditional Chinese medicine,the literature that meets the inclusion conditions is entered into the traditional Chinese medicine inheritance assistance platform,and the core composition of the drugs used,the four qi,five flavors,Composition of the Guijing and New Parties.The effective target and mechanism of core drug treatment of postoperative qi deficiency and blood stasis after PCI of coronary heart disease were predicted by network pharmacology technology.Search and screen the active ingredients and targets in the core drugs through TCMSP and other databases;The Gene Cards database was used to predict and screen the disease targets of coronary heart disease.Use STRING for protein-protein interaction(PPI)network construction;Construction of KEGG and GO pathway enrichment analysis.The active ingredients with high correlation and effective targets were screened out and the molecular docking operation was performed using Auto Dock4.2.6 software,and the Py Mol software was used for visual display.Results: A total of 65 valid literature were obtained through the inclusion criteria and exclusion criteria.Four qi,five flavors,and guijing: the most frequently used drug four qi is warm medicine,followed by cold medicine;The frequency of use of the five flavors is:sweet>bitter> bitter> sour>salty> astringent;The most frequently used menstruation is the liver,heart,and spleen.The drug pairs with high frequency of drug use were: "Danshen &Astragalus","Chuanxiong & Astragalus","Astragalus & Angelica","Chuanxiong &Danshen","Chuanxiong,Danshen & Astragalus";The high confidence in the correlation analysis was "Safflower,Chuanxiong-> Astragalus","Danshen,Angelica-> Astragalus","Safflower,Astragalus-> Chuanxiong","Angelica-> Astragalus","Chuanxiong,Danshen->Astragalus";The core drugs are: astragalus,danshen,Chuanxiong,angelica,safflower,codonopsis,licorice,peach kernel.According to the entropy clustering algorithm of the TCM inheritance assistance platform,4 potential new prescriptions can be obtained.Prescription 1:Safflower,angelica,ginseng,licorice,blood exhaustion;Prescription 2: Raw Rehmania,leech,melon,ground dragon,cooked rehmania;Prescription 3: Codonopsis,Yanhuso,Yuanzhi,Ginseng,Ginger;Prescription 4: Licorice,White Technique,Yuanzhi,Red Peony.A total of242 core drug active ingredients,261 effective compound targets,372 coronary heart disease targets,and 52 drug-disease targets were obtained for core drugs,with a total of 85 GO biological processes and 121 KEGG enrichment pathways.The top 5 key active substances were: quercetin,kaempferol,naringenin,tanshinone ⅡA,luteolin;The first four bits of effective targets were: AKT1,PTGS2,TP53,EGF;The main pathways include PI3K-Akt signaling pathway,MAPK signaling pathway,Ras signaling pathway,cAMP signaling pathway,Rap1 signaling pathway,chemokine signaling pathway,etc.The molecular docking results all had good binding activity.Conclusion: The core drugs for treating Qi deficiency and blood stasis syndrome after coronary heart disease PCI with traditional Chinese medicine are: Huangqi,Danshen,Chuanxiong,Danggui,Honghua,Dangshen,roasted licorice,and Taoren,in order to achieve the function of supplementing qi,promoting blood circulation,and resolving blood stasis;Core drugs may achieve the therapeutic purpose by inhibiting the inflammatory reaction in blood vessels,regulating the process of platelet aggregation,and improving the process of myocardial ischemia and atherosclerosis.