Analysis Of Relevant Factors Causing Laryngeal Granulation After Partial Laryngectomy

Objective:To analysis of relevant factors causing laryngeal granulation after partial laryngectomyMethods:Complete medical records of 97 patients of laryngeal cancer who underwent partial laryngectomy from January 2021 to May 2022 in our hospital.Possible risk factors of Laryngeal Granulation include age,alcohol consumption,smoking,tumour T-stage,tumour N-stage,tumour differentiation,LPR,postoperative respiratory infection,primary site of tumour,preoperative haemoglobin count,neutrophil count,monocyte count,lymphocyte count,fasting blood glucose,NLR,PLR,SII,duration of surgery,platelet count,preoperative albumin,globulin,and albumin-to-globulin ratio,which were retrospectively studied.Results:The study found that 97 patients with partial laryngectomy developed postoperative laryngeal granulation in 31 cases(32%).Statistical analysis showed that the differences in tumour T-stage and LPR between the two groups were statistically significant(p<0.05).The differences in age,alcohol consumption,smoking,tumour N stage,degree of tumour differentiation,tumour primary site,preoperative haemoglobin count,neutrophil count,monocyte count,lymphocyte count,fasting blood glucose,NLR,PLR,SII,operation time,platelet count,preoperative albumin,globulin and albumin ratio were not statistically significant between the two groups.The main risk factors associated with laryngeal granulation after partial laryngectomy were: tumour T grade(OR=2.841,95% CI: 1.037-7.081,p=0.004),LPR(OR=3.911,95% CI: 1.489-10.22,p=0.006).Statistical analysis concluded that tumour T-stage and LPR were independent risk factors for the development of postoperative laryngeal granulation.all 31 residual intralaryngeal granulations gradually regressed on their own,averaging approximately 6 months.Conclusion:This study found that tumor T grade and LPR were independent risk factors for laryngeal granulation after surgery.LPR promotes granulation in the laryngeal cavity after partial laryngectomy,and in patients with LPR,it can control the associated symptoms,thereby reducing the occurrence of laryngeal granulation.Most laryngeal granulation can be cured by conservative treatment,generally without special treatment,suggesting that postoperative close follow-up observation can be performed,without rushing surgical treatment,laryngeal granulation exists for more than three months,there is no trend of narrowing,NBI examination can be performed,and biopsy is performed if necessary.