To Explore The Relationship Between Serum VitaminD,Hyperinsulinemia And Female Infertility

Objective:In this study,a case-control study was conducted on the clinical data of 38 patients with unexplained infertility(UI)and 35 normal pregnant women.To explore the correlation between serum vitamin D level,serum insulin level and UI by comparing the relevant indexes of patients with UI and control subjects.Method:A total of 38 patients with unexplained female infertility were selected from December 2020 to January 2023 in the Obstetrics and Gynecology and Reproductive Medicine Center of our hospital.According to the Chinese expert consensus on diagnosis and treatment of unexplained infertility published in 2019,38 patients with unexplained female infertility were selected as the case group,35 women with normal pregnancy in our department and 35 women with antenatal examination at 12 weeks of pregnancy were taken as the control group.Serum 25(OH)VD,fasting blood glucose,fasting insulin,one hour postprandial serum insulin,two hours postprandial serum insulin,three hours postprandial serum insulin,insulin resistance index,age,height,weight,body mass index and previous medical history were studied.Using SPSS23.0 statistical software,the serum vitamin D level,insulin level,insulin resistance index,the prevalence rate of hyperinsulinemia and insulin resistance,the prevalence rate of vitamin D deficiency or deficiency,and the correlation between serum vitamin D level and insulin level in all subjects in the UI group and the control group were compared.Results:1.Compared with the control group,the serum insulin level of the case group was significantly higher than that of the control group at each period of time in the UI group(P<0.05).2.The insulin resistance index of the UI group was higher than that of the control group,and there was significant difference between the two groups(P<0.05),that is,the insulin resistance of the UI group was more severe than that of the control group.3.The prevalence rate of insulin resistance in UI group and control group was44.7% and 17.1%,respectively,which was significantly higher than that in control group(P<0.05).The prevalence rate of hyperinsulinemia had a similar trend between the two groups.The prevalence rate of UI group was 47.4%,while that of the control group was 14.3%.The difference was statistically significant(P<0.05),that is,the prevalence rate of hyperinsulinemia in UI group was higher.4.Compared with the control group,the serum 25(OH)VD level in the UI group was significantly lower than that in the control group(P<0.05),and the prevalence rate of vitamin D deficiency or insufficiency in the UI group was higher than that in the control group.5.Serum 25(OH)VD and serum insulin of 73 subjects in UI group and control group were statistically analyzed.Through Pearson correlation analysis,there was no significant correlation between serum 25(OH)VD level and fasting insulin level and postprandial insulin level at one hour,two hours and three hours after meal(P>0.05).Conclusion:1.The level of insulin in patients with UI was higher than that in early pregnant women with normal pregnancy,and the prevalence rate of hyperinsulinemia in patients with UI was higher.2.The level of insulin resistance is more serious and the prevalence rate of insulin resistance is higher in patients with UI.3.The serum vitamin D level of UI patients was lower than that of normal early pregnant women,and the prevalence rate of vitamin D deficiency or deficiency in UI patients was higher than that in control subjects.4.There was no significant correlation between serum vitamin D level and fasting insulin and postprandial insulin levels in one hour,two hours and three hours.