| Objective:Xianfang Huoming Yin is the prescription used via my mentor Professor Chen Shenghui for many years of ride in the therapy of male infertility diseases.In this study,the addition and subtraction of Xianfang Huoming Yin,which has the characteristic of clearing heat,detoxing and removing stasis,was used as an intervention to treat male infertility sufferers with humid warmth stasis to explore its results on high DNA fragmentation index,sperm concentration,total sperm motility,spermatozoa move forward,and clinical pregnancy results of in vitro fertilization-embryo transfer techniques.Methods:From December 2021 to August 2022,60 male infertile sufferers who met the diagnostic criteria,inclusion criteria and exclusion standards in the Reproductive Andrology Clinic of the Reproductive Andrology Hospital of Jiangxi University of Traditional Chinese Medicine had been selected,and they were divided into treatment crew and control group according to the random number table method,with 30 instances in each group.The control crew used to be treated with L-carnitine oral liquid for 12 weeks alone,and the remedy team used to be dealt with Xianfang Huoming Yin(decoction)plus L-carnitine oral liquid for 12 weeks.The general basic indicators of male age,female age and infertility years of patients in the treatment group and control group were recorded,and the conventional parameters of semen(sperm concentration,total sperm motility,forward sperm motility)of patients in the treatment group and the control group before treatment and at the 4th,8th and 12 th weeks of treatment,and the DFI indexes detected by sperm chromatin structure analysis by flow cytometry were observed,and the DFI classification,embryo transfer type and clinical pregnancy rate after embryo transfer after 12 weeks of treatment were compared.Finally,the clinical treatment effect of the two groups of patients was compared.Result:1.Before treatment,the male age,female age,infertility years,sperm concentration,complete sperm motility,sperm ahead movement,and sperm DFI indexes of patients in the therapy crew and the control team had been not statistically huge(P>0.05),which was once comparable.2.Comparison of sperm awareness and complete sperm motility between the treatment team and the manipulate group at the 4th,8th and 12 th weeks of treatment was once not statistically large(P>0.05).At the 4th and8 th weeks of treatment,there used to be no widespread difference in sperm forward motility and sperm DNA fragmentation index between the two agencies(P>0.05),however at the 12 th week of treatment,the difference in sperm concentration and sperm DFI(P<0.05)used to be statistically significant,and the therapy crew used to be better than the manage group.The sperm DNA fragmentation index values of the two corporations after12 th weeks of cure have been categorized and the distinction was statistically sizable(P<0.05),and the grade of DFI improvement in the cure crew was once higher than that of the manage group.3.Comparison of sparkling cycle transplantation and thaw cycle transplantation between therapy crew and manage team(P>0.05),the difference was once now not statistically significant,and it used to be comparable.After embryo transfer,there were 24 nice reactions in the cure group,of which 19 cases persevered to develop embryos to medical pregnancy,and the medical being pregnant charge used to be 63.333%(19/30).There were 19 wonderful pregnancy reactions in the control group,of which 12 instances persisted to advance embryos to scientific pregnancy,and the medical pregnancy rate used to be 40%(12/30).Although there was once no widespread scientific being pregnant rate between the two corporations(P>0.05),the quantity of clinical pregnancies in the remedy group used to be greater than that in the manage group.According to the classification of sperm DNA fragmentation index and clinical being pregnant rate,the scientific efficacy of the two agencies was once statistically full-size(P<0.05),and the remedy group used to be higher than the control group.Conclusion:The addition and subtraction of Xianfang Huoming Yin combined with L-carnitine oral liquid for the cure of male infertility patients with moist warmth stasis can considerably enhance the DNA injury of excessive sperm and decrease the sperm DNA fragmentation index value after 12 weeks of treatment,which can amplify the percentage of desirable sperm DNA integrity(DNA fragmentation index<15%)compared with the manage team using L-carnitine oral liquid alone.It can also make bigger the range of clinical pregnancy instances after embryo transfer and improve the medical treatment effect.There have been no most important destructive events at some stage in the trial.Xianfang Huoming Yin has a desirable impact in the therapy of sperm DNA harm and improve clinical pregnancy,and it is recommended to use built-in standard Chinese remedy and Western medicine to treat male infertility diseases. |
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