The Effect Of TyG Index And Different Renal Function Status On The Prognosis Of Patients With Acute Coronary Syndrome

Objectives:To investigate the effect of triglyceride glucose product index(TyG)and different renal function status on the prognosis of patients with acute coronary syndrome.Methods:The clinical data of patients with acute coronary syndrome who underwent coronary angiography in our hospital from January 2020 to June 2020 were retrospectively analyzed,and the TyG index and eGFR were calculated.According to the median of TyG index,they were divided into group Q1 and group Q2;According to eGFR,they were divided into moderate and severe renal insufficiency group and normal renal function group.Analyzing the clinical characteristics of patients and the occurrence of major adverse cardiovascular events(MACE)during the follow-up period,and drawing Kaplan-Meier curve to explore the relationship between TyG index and the adverse prognosis of ACS patients.Analyzing the TyG index to predict the risk of death in patients with acute coronary syndrome by using the receiver operating characteristic curve(ROC).Results:During the 30-month follow-up,the incidence of MACE was 20.5% and 31% in group Q1 and group Q2,and 21.1% and 41.1% in normal renal function group and moderate to severe renal insufficiency group,respectively.The difference was statistically significant(P<0.05).Kaplan-Meier curve showed that the survival rate of group Q1 was higher than that of group Q2,and the survival rate of normal renal function group was higher than that of moderate and severe renal insufficiency group,the difference was statistically significant(log-rank P<0.05).Binary Logistic regression analysis showed that diabetes(OR =1.971,95 % CI 1.080-3.594,P < 0.05)and TyG index(OR = 1.647,95 % CI 1.051-2.580,P< 0.05)were associated with MACEs in ACS patients.ROC curve analysis showed that TyG index had certain prognostic value for ACS patients(AUC = 0.621).Conclusions:The high TyG index and the decrease of eGFR are related to the poor prognosis of ACS patients,and the causal relationship between them and coronary atherosclerosis needs to be further confirmed by prospective research.