| Objective:To observe the levels of serum inflammatory markers in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)of different severity and their relationship with sleep parameters changes in patients with OSAHS,in addition,to explore whether the severity of OSAHS patients is correlated with anxiety,depression and mental status.Methods:Collect patients who received polysomnography(PSG)at the First Hospital of Shanxi Medical University due to snoring and suspected snoring during nighttime sleep as the research subjects.Blood specimen were collected to detect the level of inflammatory markers in the body.At the same time,Epworth sleepiness scale(ESS),self-rating anxiety scale(SAS)and self-rating depression scale(SDS)were filled in to evaluate sleepiness,anxiety and depression.Results:1.34.6% were female,65.4% were male,the average age was 35.8±10.8 years,the height was in the range of(168.42±8.47)cm,the weight was in the range of(74.35±15.71)Kg and the BMI was in the range of(26.0±3.9).2.The level of sTNFR I in OSAHS patients was positively correlated with AHI(r=0.821,P<0.001),and negatively correlated with the lowest SpO2 and average SpO2(r=0.719,r=0.685,P<0.001).CRP was positively correlated with AHI(r=0.683,P<0.001),and negatively correlated with minimum SpO2 and average SpO2(r=-0.552,r=-0.519,P<0.001).IL-6 was positively correlated with AHI(r=0.814,P < 0.001),and negatively correlated with lowest SpO2 and average SpO2(r=-0.730,r=-0.704,P <0.001).PCT had no correlation with AHI,minimum SpO2 and average SpO2.NLR was positively correlated with AHI(r=0.379,P<0.001),and negatively correlated with lowest SpO2 and average SpO2(r=-0.456,P<0.001;r=-0.414,P=0.003).3.sTNFR I predicted severe OSAHS with a threshold value of 749.5,sensitivity of86.1% and specificity of 92.9%.CRP predicted severe OSAHS with a threshold value of3.61,sensitivity of 83.3% and specificity of 73.8%.IL-6 predicted severe OSAHS with a threshold value of 2.9,sensitivity of 100% and specificity of 71.4%.NLR predicted severe OSAHS with a threshold value of 1.63,sensitivity of 100% and specificity of 52.4%.PCT did not have the ability to predict OSAHS severity.There were no markers of inflammation that predicted mild and moderate OSAHS.4.The severity of OSAHS was correlated with daytime sleepiness,anxiety and depression symptoms,and AHI was positively correlated with ESS,SAS and SDS scores(r=0.708,r=0.292,r=0.648,P<0.05).The lowest SpO2 and average SpO2 were negatively correlated with ESS score(r=-0.556,r=-0.570,P<0.05),and had no significant correlation with SAS score(P>0.05),but were negatively correlated with SDS score(r=-0.481,r=-0.482,P<0.05).Daytime sleepiness was also correlated with anxiety and depression symptoms.ESS scores were positively correlated with SAS and SDS scores(r=0.329,r=0.540,P<0.05).Conclusion:1.OSAHS has a great influence on the level of inflammatory markers in the body.Except PCT,other indicators increase with the increase of OSAHS severity.Early measurement of inflammatory markers in OSAHS patients can assess the severity of disease in OSAHS patients,reflect the level of inflammation in the body,and predict the risk of OSAHS-related complications.2.sTNFR I has the strongest ability to predict severe OSAHS,there are no inflammatory markers that can predict mild to moderate OSAHS.3.The more severe OSAHS patients are,the more likely they are to show symptoms of anxiety and depression.The more severe the daytime sleepiness,the more obvious the anxiety and depression symptoms. |
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