Observation On The Effects Of Combined Use Of TEAS At PC6 And Droperidol For QT Interval In Patients Undergoing Gynecological Laparoscopy

Objective:The research aims To observe the effect of combined use of transcutaneous electrical acupoint stimulation（TEAS）at PC6 and droperidol on QT interval in patients undergoing gynecological laparoscopic surgery.Methods:Eighty gynecological patients aged 18～50 years old,BMI of 18～29.5 kg/m²,ASA grade I～II,and undergoing laparoscopic surgery in general anesthesia were selected and randomly divided into groups including C（controlled group）,E（TEAS group）,D（droperidol group）,and E+D（TEAS combined droperidol group）.There were 20 cases in each group.Patients in group C were given 2ml of 0.9%sodium chloride injection intravenously after intubation,group E were given TEAS at PC6 for 30min pretreatment before surgery in the anesthesia preparation room,group D were given droperidol 1mg intravenously after intubation,and group E+D were given TEAS at PC6 30min pretreatment in the anesthesia preparation room before surgery,and droperidol 1mg intravenously after intubation.Electrocardiograms（ECG）were recorded after induction of general anesthesia,the QTc,QTcd,Tp-Te,Tp-Te/QT values of patients before administration（T₀）and 5 min（T₁）、10 min（T₂）、15 min（T₃）,30 min（T₄）and 60 min（T₅）after administration were recorded and calculated,as well as the heart rate,mean arterial pressure,and bispectral index（BIS）at the above time points.The severity of nausea and vomiting 5 days after operation was recorded.Results:（1）There was no significantly statistical difference in baseline data such as age,weight,BMI,ASA classification,time and type of operation,education level,history of smoking and motion sickness,HAD score and Apfel score of the four groups（P>0.05）.（2）There was no statistical difference in HR,MAP and BIS indexes between the four groups at the same time（P>0.05）,and no significant difference in HR,MAP and BIS indexes at each time point of T₀～T₅in each group（P>0.05）.（3）Effects of TEAS at PC6 on QT interval in patients with droperidol:（1）There was no significant difference in QTc,QTcd,Tp-Te,Tp-Te/QT indexes in group C and group E at the same point;And no significant differences in QTc,QTcd,Tp-Te,Tp-Te/QT indexes at each time point of T₀～T₅.（2）Compared with group C,QTc was significantly increased at T₂（P<0.05）,QTcd,Tp-Te,Tp-Te/QT indexes were not statistically different,QTc and Tp-Te were significantly increased at T₃ and T₄（P<0.05）,QTcd and Tp-Te/QT indexes were not statistically different,and there was no significant difference in QTc,QTcd,Tp-Te,Tp-Te/QT at T₀,T₁ and T₅ in group D.Compared with T₀,QTc in group D was significantly increased（P<0.05）at T₂,T₃,T₄ and T₅,and there was no significant difference in QTc index at T₁.Tp-Te in group D was significantly increased（P<0.05）at T₃ and T₄,and no significant differences in Tp-Te indexes in T₁,T₂ and T₅.There were no significant differences in QTcd,Tp-Te/QT indexes at T₁,T₂,T₃,T₄ and T₅.（3）Compared with group D,Tp-Te values were significantly reduced at T₃（P<0.05）,QTc,QTcd and Tp-Te/QT were significantly reduced in T₄,QTc and Tp-Te values were significantly reduced at T₄（P<0.05）,QTcd and Tp-Te/QT indexes were not statistically different,and no significant differences in QTc,QTcd,Tp-Te,Tp-Te/QT at T₀,T₁,T₂ and T₅ in group E+D.Compared with T₀,QTc in E+D group was significantly increased at T₃（P<0.05）,there were no significant differences in Tp-Te,QTcd and Tp-Te/QT indexes,QTc and Tp-Te were significantly increased at T₄（P<0.05）,QTcd,Tp-Te/QT indexes were not statistically different,and no significant difference in QTc,QTcd,Tp-Te,Tp-Te/QT at T₁,T₂ and T₅.Conclusion:TEAS at the PC6 by itself has no significant effect on the QT interval and significantly shortens the prolongation of the QT interval in patients with droperidol-induced.TEAS at the PC6 combined with droperidol has a better effect on preventing postoperative nausea and vomiting than any single drug or non-pharmacological intervention.