Study On The Application Of Magnetic Control Capsule Endoscopy In Healthy People In Shanxi Province

Objective:The clinical characteristics and related factors of gastrointestinal diseases in Shanxi Province were studied by summarizing and analyzing the results of magnetically controlled capsule endoscopy and related laboratory tests among healthy people in Shanxi Province,in order to evaluate the clinical application value of magnetically controlled capsule endoscopy in the digestive tract of healthy people.Methods:A total of 1352 healthy subjects were selected from January 2019 to December 2021in the Physical Examination Center and Out-of-hospital Health Examination Center of Shanxi Provincial People’s Hospital.Magnetic control capsule endoscopy was performed for the subjects,together with laboratory tests such as gastrin 17,pepsinogen level and¹³C breath test.In combination with general information such as age,gender,education level,and dietary habits,the characteristics,lesion detection rate and other correlations of gastrointestinal diseases among healthy physical examination population in Shanxi Province were analyzed.Results:1.The detection rates of gastrointestinal diseases in healthy people by magnetic capsule endoscopy were 99.8%（1350/1352）,31.4%（116/370）and 1.4%（5/370）respectively.2.In the examination of upper digestive tract lesions in healthy people by magnetic control capsule endoscopy,the detection rate of esophageal lesions was 15.6%,among which the detection rate of reflux esophagitis was the highest,and the detection rate of women was higher than that of men.There were 1284 cases（95%）of chronic non-atrophic gastritis and 45 cases（4.3%）of chronic atrophic gastritis,and there was no statistical difference in sex and age between the two diseases（P>0.05）.In the detection rate of gastric polyps,the detection rate of women was significantly higher than that of men（64.2%,P=0.022）,and the lesions were mostly found in the stomach body（68/137）and the stomach floor（52/137）.The incidence of gastric erosion increased gradually with age,accounting for 77.5%over 40 years old,with a P value of 0.039.There were 55cases of gastric ulcer.Although there was no difference in sex and age（P>0.05）,it was found that gastric ulcer mostly occurred in gastric antrum（35/55）,and 28 cases had multiple ulcers.Among 1352 cases,26 cases（1.92%）were diagnosed as gastric tumors,including 2 cases of gastric cancer（0.13%）and 24 cases of submucosal tumors（1.78%）.These two patients with gastric cancer are all over 40 years old,and they have no obvious symptoms of abdominal discomfort.Among the 24 cases of submucosal tumors found,there were more men than women（75%,P=0.014）,and the study showed that the detection rate increased with age（70.8%,P=0.04）.3.Among 370 healthy people who completed the magnetic control capsule endoscopy of the middle and lower digestive tract,the detection rate of magnetic control capsule endoscopy of the middle digestive tract was 32.7%,the most common lesion was enteritis in 43 cases（3.2%）,followed by duodenitis.Magnetic capsule endoscopy detected 5 cases of lower digestive tract diseases,the detection rate was 1.4%,including1 case of colon ulcer and 4 cases of colon polyp.4.Among 1352 healthy people,540 cases were HP positive in 13C breath test,and the positive rate was 40.0%.And the study confirmed that there was a clear correlation between HP infection and chronic atrophic gastritis（P=0.001）,and there was a correlation between HP infection and gastric ulcer,submucosal tumor,erosion and reflux esophagitis（P<0.05）.Laboratory examination showed that the levels of pepsinogen and gastrin in patients with gastric ulcer,gastric polyp and chronic atrophic gastritis were significantly higher than those in patients with no abnormality in the stomach under magnetic control capsule endoscopy,and the lesions were correlated with pepsinogen and gastrin levels（P<0.05）.Conclusion:1.Magnetic capsule endoscopy can effectively complete the screening and diagnosis of small intestinal diseases while completing the upper gastrointestinal examination,and it is an effective tool for early detection and early diagnosis of gastrointestinal diseases in healthy people.2.The detection rate of digestive tract diseases in Shanxi province is similar to that of domestic related research.3.Laboratory tests such as gastrin-17 and pepsinogen,and¹³C breath test combined with magnetic capsule endoscopy are helpful for the detection of digestive tract diseases,which can be used as an important auxiliary means for digestive tract screening of healthy people.