Correlation Analysis Of Serum Uric Acid Level With Bone Mineral Density And Bone Turnover Markers In Young And Middle-Aged Male Gout Patients

Objective:To investigate the correlation between serum uric acid and bone mineral density and bone turnover markers in young and middle-aged male gout patients.Methods:A total of 110 young and middle-aged male gout patients who were treated or hospitalized in the Rheumatology and Immunology Department of Fenyang Hospital affiliated to Shanxi Medical University from January 2018 to October 2021 were included according to the inclusion and exclusion criteria.Collect basic clinical data of patients,including age,height,weight,etc.Detect general biochemical indicators such as SUA,blood lipids,liver and kidney function,calcium,phosphorus,etc.Test BTMs,including osteocalcin(OC),β-caroxyl terminal peptide(β-CTX)and total type I collagen N-terminal peptide(PINP);The BMD of the patient’s lumbar spine(L1-L4)and left femoral neck was measured using a dual energy X-ray bone densitometer(DXA).According to the measured SUA level,patients were divided into three groups: low blood uric acid level S1 group(≤ 420 umol/L),medium blood uric acid level S2 group(420-600 umol/L),and high blood uric acid level S3 group(≥ 600 umol/L).The differences in basic data,general biochemical indicators,BMD,and BTMs among the three groups were compared.Pearson correlation analysis and multiple linear regression analysis were used to determine the relationship between SUA levels and lumbar spine,left femoral neck BMD,and BTMs.Results:1.SUA,TG,PTH,25(OH)D,lumbar spine BMD and β-CTX were statistically different between the groups(P<0.05).2.Correlation analysis showed that SUA was negatively correlated with left femoral neck BMD in all three groups,with statistical significance only in group S2(r =-0.502,P<0.05),and in groups S2 and S3,SUA was negatively correlated with lumbar spine BMD,and all were statistically significant(r =-0.560,r=-0.491;all P<0.05).There were no significant correlations between SUA and lumbar spine,left femoral neck BMD and BTMs after correction for various confounding factors that interfered.Conclusion:In middle-aged and young male gout patients,this study did not find a correlation between SUA levels,BMD,and BTMs after adjusting for confounding factors.