Correlation Between TyG Index And Left Ventricular Diastolic Function In The Non-heart Failure Elderly Patients With Hypertension

Objective:By using multiple echocardiographic parameters to assess changes in left ventricular remodeling and diastolic function in the non-heart failure elderly patients with hypertension.To analyze the correlation between TyG-index and LV diastolic function and explore the relevant factors influencing diastolic function in the patients.Methods:This study is a retrospective analysis of the elderly hypertensive patients.A total of220 elderly patients diagnosed with essential hypertension were randomly selected as the hypertension group,and at the same time to select healthy elderly patients 140 cases as the control group.Collecting relevant data of patients:(1)General data: gender,age,height,weight,BMI,smoking history,SBP,DBP,heart rate.(2)Biochemical data:FPG,TC,TG,HDL-C,LDL-C,then multiple FPG and TG to calculate TyG index;(3)Echocardiographic data: Conventional echocardiography parameters: IVST,LVPWT,LVEDd,LVEDV,LVESV,LVEF,then to calculate LVMI and RWT.Spectrum Tissue Doppler Echocardiography Parameters: E peak,A peak,mitral valve ring early diastolic peak velocity(e’),late diastolic peak velocity(a’),IVRT,TRPV,calculate E/A,E/e’,e’/a’;the left atrial maximal volume was measured by tracing the left atrial intimal profile,then calculating the left atrial volume index(LAVI);and the left ventricular remodelling was determined according to Ganau classification.By using SPSS 25.0 to analyse the data,Pearson correlation analysis was used to evaluate the correlation between TyG index and left ventricular diastolic function,and multiple linear regression models were established to analyse the influence of various factors on left ventricular diastolic function.Results:1.Two groups of patients in the gender,age,smoking history,heart rate,TC,TG,LDL-C differences of no statistical significance(P>0.05);compared with healthy controls,patients in the elderly hypertensive group had higher date in BMI,SBP,DBP,FPG,TyG index,and incidence of ventricular remodelling,and lower date in HDL-C,with statistically significant differences(P<0.05).2.LVEF was greater than 50% in all enrolled patients,and there was no statistical difference;routine echocardiographic parameters,such as LVEDV,LVESV,IVST,LVPWT,LVEDd,LVMI,RWT,were increased in the hypertensive group compared to healthy controls,and the difference was statistically significant(P<0.05).3.Two groups of patients have no differences in E peak and a’(P>0.05).The parameters of A peak,E/A,E/e’,IVRT,TRPV and LAVI were increased in the elderly hypertensive group compared with the healthy control group,and the parameters of E/A,e’,e’/a’ were decreased,and the differences were statistically significant(P<0.05).4.Pearson correlation analysis showed that the TyG index was positively correlated with E/e’,TRPV,and LAVI(r=0.202,P<0.0001;r=0.118,P=0.042;r=0.238,P<0.0001)and the parameter of e’/a’(r=-0.138,P=0.011)was negatively correlated with E/e’.5.Multiple linear regression model analysis showed that age(β=0.178,P<0.0001),sex(β=1.11,P=0.034),SBP(β=0.052,P<0.0001),ventricular remodelling(β=1.781,P=0.001)and TyG index(β=0.451,P=0.041)had significant effects on E/e’ and can be considered as an independent influence of LV diastolic function.Conclusions:1.Although systolic function remains normal in elderly hypertensive patients,there may be latent left ventricular diastolic impairment and ventricular remodelling.Reporting of left ventricular diastolic function parameters,such as E/e’,should be incorporated into clinical diagnosis and management.2.The increase in the TyG index in the elderly hypertensive population indicates a decline in left ventricular diastolic function,which may provide a convenient indicator for clinical assessment of diastolic function.3.Age,female sex,systolic blood pressure,ventricular remodelling and TyG index are independent risk factors for left ventricular diastolic dysfunction in elderly patients with hypertension.