Study On The Correlation Between Acute ST-Segment Elevation Myocardial Infarction And Serum RNA Binding Proteins TBL2

Objective:1.To investigate the correlation between acute ST-segment elevation myocardial infarction and serum level of RNA binding proteins TBL2 in patients.2.To explore the diagnostic value of serum RNA binding proteins TBL2 in acute STsegment elevation myocardial infarction.Methods:1.According to the inclusion and exclusion criteria,40 hospitalized patients with STEMI in Department of Cardiovascular Medicine of our hospital from December 2021 to December 2022 were selected as the experimental group.40 people without myocardial infarction in physical examination center of our hospital were selected as the control group.2.Collect and record clinical data of all subjects,and statistically analyzed it.3.Collect the subjects’ venous blood 5ml,and centrifugate it.The serum was taken after centrifugation and stored in the refrigerator at-80℃.The serum TBL2 level was measured by ELISA,and the experimental results were statistically analyzed.4.STEMI patients were grouped according to gender and the number of diseased vessels to compare serum TBL2 levels among all groups.5.Spearman correlation analysis was used to compare the correlation between serum TBL2 level and clinical indicators.6.Logistic multivariate analysis was performed to explore the influencing factors of STEMI,and ROC curve was used to evaluate the diagnostic value of serum TBL2 in STEMI.Results:1.There were no significant differences in gender,age,BMI,DBP,drinking history,diabetes history,SCr,TC,TG and LDL-C between the two groups(P>0.05).The differences among SBP,smoking history,hypertension history,WBC,UA,HDL-C were statistically significant(P<0.05).2.Serum TBL2 level in STEMI patients was significantly higher than that in people without myocardial infarction,and the difference was statistically significant(P<0.001).3.STEMI patients were compared according to gender and number of diseased vessels.The results showed no significant differences in serum TBL2 levels among all groups(P>0.05).4.Spearman correlation analysis between serum TBL2 level and clinical indicators showed that serum TBL2 level was positively correlated with hypertension history(r=0.298,P=0.007),WBC(r=0.527,P<0.001)and UA(r=0.295,P=0.008),and was negatively correlated with HDL-C(r=-0.421,P<0.001).5.Logistic multivariate analysis showed that in serum TBL2,WBC,UA,HDL-C and other factors,the OR and 95%CI of serum TBL2 level were greater than 1,and P<0.05,indicating that the result was statistically significant.6.ROC curve analysis showed that the optimal cut-off point of serum TBL2 for the diagnosis of STEMI was 2.559ng/mL,the AUC was 0.972,the 95%CI was 0.944～1.000,the sensitivity was 0.925,the specificity was 0.900,P<0.001.It is suggested that serum TBL2 has a certain diagnostic value for STEMI.Conclusion:1.Serum TBL2 level in STEMI patients is significantly higher than that in people without myocardial infarction,but it is not related to gender or the number of diseased vessels.In addition,Logistic multivariate analysis showed that elevated serum TBL2 level is an independent risk factor for STEMI,suggesting that TBL2 may be involved in the development of STEMI.2.Serum TBL2 level was positively correlated with hypertension history,WBC,UA,and negatively correlated with HDL-C.3.Serum TBL2 has certain diagnostic value for acute ST-segment elevation myocardial infarction,and is expected to a serological index for the diagnosis of acute ST-segment elevation myocardial infarction.