| Objective: To investigate the clinical efficacy of Qingjin Jiedu Decoction combined with Cefixime Granules in the treatment of children with acute tonsil heat and toxic accumulation syndrome,evaluate its efficacy and safety,and provide reference for the treatment of this disease.Methods: In this study,a total of 70 children with acute tonsillitis who met the diagnostic criteria of traditional Chinese medicine and western medicine and were classified as heat-toxin accumulation syndrome were collected.Son.A total of 70 children were randomly divided into a treatment group and a control group,with 35 cases in each group.After being excluded and dropped out,the treatment group and the control group were finally included in 31 cases and 30 cases respectively,with a total of 61 cases.The control group was treated with Cefixime Granules,and the treatment group was additionally treated with Qingjin Jiedu Decoction,a traditional Chinese medicine without decoction,on the basis of the control group,for a total of 7days.During the treatment,follow-up was conducted,and the quantitative scores of syndromes before and after the treatment were observed and recorded,and statistical analysis was carried out.(1)Total clinical curative effect: The research results show that both the treatment group and the control group can improve the clinical curative effect of the children.And the difference was significant(P<0.05),so the treatment group was better than the control group in improving the total curative effect.(2)The total score of syndrome: comparison within the group: the results showed that the total score of syndrome,the total score of the main symptom and the sub-symptom between the two groups were significantly different(P<0.05),which was statistically significant,that is,the symptoms in the two groups were improved after treatment;Comparison between groups: The results showed that the total score of syndrome,the total score of main symptoms and secondary symptoms in the two groups were significantly different(P<0.05),and there was statistical significance.better than the control group.(3)The scores of major and minor symptoms: The two groups of children were compared within the group: the results showed that the two groups of children had tonsil congestion and swelling,tonsil secretions,sore throat,fever,upset,cough,thirst,bad breath and dry stool scores.There was a statistically significant difference between the two groups(P<0.05),indicating that both the treatment group and the control group could improve the scores of the main symptoms and secondary symptoms;comparison between groups: tonsil congestion and swelling,tonsil secretions,sore throat,upset,cough after treatment,thirst,bad breath and dry stool scores were different between groups(P<0.05),which was statistically significant,and each score in the treatment group decreased more,indicating that the treatment group was better than the control group in reducing the above-mentioned main symptoms and secondary symptoms..There was no significant difference in the fever score of secondary symptoms(P>0.05),and there was no statistical significance.(4)Comparison of the antipyretic time between the two groups: there was significant difference in the antipyretic time between the two groups(P<0.05),both of which were statistically significant,indicating that the treatment group was better than the control group in terms of the antipyretic time.(5)Comparison of WBC,N%,and CRP between the two groups of children:Comparison within the group: After treatment,the indexes of the two groups of children were significantly decreased,and the difference was significant(P<0.05),which was statistically significant;indicating that both groups were effective in improving the above indexes.Comparison between groups: After treatment,there was no significant difference between the two groups(P>0.05),and there was no statistical significance,indicating that the two groups had the same effect in improving the above indicators.(6)The two groups of children were regularly followed up for drug safety during the treatment process.No clinical adverse events occurred in both groups,and the drug safety was good.Conclusion: This study confirmed that Qingjin Jiedu Decoction combined with Cefixime Granules can effectively reduce the TCM syndrome score of acute tonsil heat and poison accumulation in children,and the clinical effect is positive.In terms of improving clinical syndrome scores,Qingjin Jiedu Decoction combined with Cefixime Granules and Cefixime Granules can improve tonsil congestion and swelling,tonsil secretions,sore throat,fever,upset,cough and expectoration,thirst,bad breath,Dry stool syndrome points.Qingjin Jiedu Decoction combined with Cefixime Granules has more advantages than Cefixime Granules alone in improving the primary and secondary symptoms except fever,and has the same effect as Cefixime Granules in improving fever symptoms,but the antipyretic time is shorter.In the improvement of WBC,N%,and CRP,the two groups after treatment were significantly lower than those before treatment,and the improvement effect was comparable.There were no adverse reactions during the treatment of children taking Qingjin Jiedu Decoction combined with Cefixime Granules,which provides a new clinical syndrome differentiation idea and treatment method for the clinical treatment of children with acute tonsil heat and toxic accumulation syndrome,which is worthy of promotion. |
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