| ObjectiveBy reviewing the data of the four diagnoses of patients diagnosed with type 2diabetes combined with hyperlipidemia and the related risk factors and physicochemical indexes,such as age,disease duration,blood pressure,glycated hemoglobin,total cholesterol,triglycerides,low-density lipoprotein,high-density lipoprotein,serum uric acid,and serum creatinine,we summarize the distribution characteristics of the four diagnoses of Chinese medicine and the distribution pattern of pathological syndromes in patients diagnosed with type 2 diabetes combined with hyperlipidemia,And the correlation between pathological syndromes and their risk factors in each group.The correlation between pathological syndromes and their risk factors in thirst turbid patients was analyzed from the perspective of traditional Chinese medicine.MethodsIn accordance with the Western medical diagnostic criteria for type 2diabetes and hyperlipidemia,diagnostic criteria of Chinese medicine,and inclusion and exclusion criteria,eligible patients with type 2 diabetes and hyperlipidemia from January 2022 to December 2022 at the Department of Endocrinology were screened for the four diagnostic data and relevant risk factors physicochemical indexes,which were recorded on the case record form.Using the relevant statistical software,statistical analysis was performed on the collected data of four diagnoses of patients who met the criteria according to the syndrome score statistics were performed on the symptoms,signs,and tongue veins collected this time,and those with a total syndrome score of ≥ 70 points were counted.Significant differences in relevant risk factors for type 2 diabetes and hyperlipidemia were analyzed according to pathogenic syndromes in different subgroups,and finally the results of this study were discussed from the perspective of traditional Chinese medicine(TCM)to reach a conclusion.Results1.Results The data of 174 cases of type 2 diabetes with hyperlipidemia were collected.156 cases had the score of the most pathogenic syndrome element ≥ 70 points.Among them,there are 75 males and 81 females.The main age of onset was 61 to 90 years old.The course of disease was 45 cases under 5 years,45 cases in 6-10 years,17 cases in 11-15 years,30 cases in 16-20 years,and 21 cases over21 years.2.The collected 156 cases of type 2 diabetes patients with hyperlipidemia with disease nature syndrome element score ≥ 70 points were characterized by four diagnostic data of traditional Chinese medicine: 88 different symptoms,tongue and pulse were counted.Among the symptoms,dry mouth 115 times,excessive drinking 89 times,limb skin numbness 89 times,turbid urine 58 times,fatigue 56 times,bitter mouth 51 times,chest tightness 48 times,insomnia 46 times,blurred vision 41 times,dizziness 40 times,these symptoms occur more frequently.Among the tongue veins,the tongue is light purple 55 times,the coating is thin and white 50 times,and the pulse is thin 33 times.3.Statistics a total of 13 pathogenic syndrome elements,including Yin deficiency(101 cases),27.7%,dampness(48 cases),13.2%,phlegm(38 cases),10.4%,heat(36 cases),9.9%,Yang deficiency(33 cases),9.1%,Qi deficiency(33cases),9.1%,blood deficiency(31 cases),8.5%,dryness(18 cases),4.9%,blood stasis(15 cases),4.1%,Jin deficiency(4 cases),1.1%,water withdrawal(4 cases),1.1%,yang hyperactivity(2 cases),0.5%,Qi Stagnation(1 case),0.3%.4.Data analysis: age(Kruskal-Wallis=17.748,P=0.007 < 0.05).Course of disease(Kruskal-Wallis=18.004,P=0.006<0.05).Systolic blood pressure(F=0.498,P=0.810>0.05).Diastolic pressure(F=1.615,P=0.142>0.05.BMI(Kruskal-Wallis=122.011,P=0.001<0.05).Glycated hemoglobin(Kruskal-Wallis=5.973,P=0.461>0.05).Triglyceride(Kruskal-Wallis=12.402,P=0.054>0.05).Cholesterol(Kruskal-Wallis=46.560,P=0.000<0.05).Low density lipoprotein(Kruskal-Wallis=2.235,P=0.897>0.05).High density lipoprotein(Kruskal-Wallis=9.699,P=0.138>0.05).Blood uric acid(Kruskal-Wallis=0.987,P=0.986>0.05).Blood creatinine(Kruskal-Wallis=9.304,P=0.157>0.05).5.7 Multiple pairwise comparisons among the syndrome elements were made,and the significant differences were adjusted by Bonferoni correction method.The results showed that there was no significant difference in age between the groups(P>0.05).Multiple paired comparisons among the seven syndrome elements suggest that there is a significant difference between the heat group and the phlegm group in the course of disease(Bonferrnoi=66.156,P=0.043<0.05).Compared with the median level among the groups,the phlegm group is higher than the heat group,and there is no significant difference between the other two groups.Multiple pairwise comparisons among the seven syndrome elements showed that the total cholesterol blood deficiency group had significant differences compared with the wet group and the phlegm group(Bonferroi=69.418,76.558,P=0.024,0.013<0.05),and the yin deficiency group had significant differences compared with the wet group and the phlegm group(Bonferroi=-51.115,-58.255,P=0.034,0.002<0.05).Compared with the median level between the groups,the blood deficiency group and the yin deficiency group were lower than the wet group and the phlegm group,and the other two groups had no significant differences.Multiple pairwise comparisons among the seven syndrome elements suggest that there are significant differences between BMI yin deficiency group and damp group,yin deficiency group and phlegm group,heat group and phlegm group,yang deficiency group and phlegm group,blood deficiency group and phlegm group,and qi deficiency group and phlegm group(Bonferroi=-56.272,-106.018,104.490,99.086,96.813,77.966,P=0.011,0.000,0.000,0.000,0.000,0.010<0.05).The results show that the wet group is higher than the yin deficiency group,and the phlegm group is higher than the yin deficiency group.The heat group,qi deficiency group,yang deficiency group and blood deficiency group are all high,and there is no significant difference between the other two groups.Conclusion156 cases of type 2 diabetes patients with hyperlipidemia in this collection are mainly middle-aged and elderly patients.The disease syndrome elements include yin deficiency,dampness,phlegm,heat,qi deficiency,yang deficiency,and blood deficiency.The overall pathogenesis is based on the deficiency of the root and the excess of the root,with yin deficiency as the root,and damp phlegm heat as the root.There may be manifestations of qi deficiency,yang deficiency,and blood deficiency.For patients with hypercholesterolemia,obesity,and overweight type 2 diabetes combined with hyperlipidemia,we can treat them from phlegm and dampness.When strengthening the spleen and removing phlegm and dampness,we can adjust the diet results,exercise properly,and control reasonable target weight.Patients with heat syndrome are prone to phlegm syndrome with a long course of disease. |
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