Clinical Observation Of The Correlation Between Gastric Polyps And Hp Infection,G-17 And Pepsinogen

Objectives: To observe the correlation between Hp infection,serum G-17 and PG and the occurrence of gastric polyp through the control study of gastric polyp group and non-gastric polyp groups(chronic non-atrophic gastritis group)in patients with chronic non-atrophic gastritis.The correlation of pathological type,number,position and size of gastric polyps with Hp infection,G-17 and PG indexes was analyzed.To explore the related factors of gastric polyp,provide theoretical support for preventing the occurrence and development of gastric polyp,and reduce the incidence of some gastric polyps canceration.Methods: This study is a retrospective case-control analysis.According to the inclusion and exclusion criteria,172 inpatients from January 2021 to January 2023 in the Calmette Hospital affiliated to Kunming Medical University were selected.Basic and clinical data(Hp infection,G-17,pepsinogen,blood lipid and gastroscopy results)were collected.According to the gastroscopy results,the patients were divided into chronic non-atrophic gastritis with gastric polyp group(observation group)and chronic non-atrophic gastritis group(control group).1.The differences of Hp infection rate,G-17,pepsinogen,blood lipid levels,smoking history and drinking history of the observation group and the control group were analyzed.To observe the correlation between Hp infection,G-17,PG,blood lipids,smoking,drinking history,and the occurrence of gastric polyp.2.The observation group was divided into different subgroups according to the pathological type,number,position and size of gastric polyps,and then the Hp infection rate,G-17 and PG indexes were compared with the control group.The correlation between the pathological type,number,size of gastric polyps and Hp infection rate,G-17,PG was analyzed.3.The related factors of fundic gland polyp and gastric hyperplastic polyp were analyzed by logistics regression analysis to explore the related factors of gastric polyp.Results:1.There were no significant differences in gender,age,Hp infection rate,serum G-17,PG I,PG II,PGR,blood lipids,smoking history,and drinking history between the observation group and the control group(P > 0.05).When G-17 was positive,PGII level in the observation group(polyp group)was lower than that in the control group(P=0.005).2.According to the pathological type of gastric polyp,the gastric polyps were divided into FGP group and GHP group,and then compared with the control group in Hp infection rate,G-17 and PG indexes:The level of PGR in gastric hyperplastic polyp group was higher than that in control group(P=0.044).3.According to the number of gastric polyps,the gastric polyps were divided into single polyp group and multiple polyps group.There was no significant difference in Hp infection rate,G-17 and PG indexes between the two groups and the control group(P > 0.05).There were no significant differences in Hp infection rate,G-17 and PG indexes between single polyp group and multiple polyps group in FGP group.4.According to the size of gastric polyp,the gastric polyps were divided into<0.5 cm group,0.5-1.0 cm group,and>1.0 cm group.There was no significant difference in Hp infection rate,G-17,and PG indexes between the three groups and the control group(P > 0.05).5.According to the location of gastric polyp,the gastric polyps were divided into gastric fundus polyp group and gastric body polyp group,and then the Hp infection rate,G-17 and PG indexes were compared between the two groups and the control group: The positive rate of G-17 was significantly different(P=0.003),specifically,control group(53.3%)> gastric body polyp group(36.1%)> gastric fundus polyp group(21.6%).6.There were significant differences in PGR levels among the gastric fundus polyp group,the gastric body polyp group,and the control group,as follows: The PGR level in the gastric body polyp group was significantly higher than that in the control group(P=0.001)and the gastric fundus polyp group(P=0.003),while there was no significant difference between the control group and the gastric fundus polyp group(P>0.05).In the FGP group,the PGR level in the gastric body polyp group was significantly higher than that in the gastric fundus polyp group(P=0.049).7.Logistic regression analysis of fundic gland polyp: Age(P=0.016)and gender(P=0.040)are related to the occurrence of fundic gland polyp.Patients with fundic gland polyp are mostly female and older patients.Logistic regression analysis of gastric hyperplastic polyp: PGR is related to gastric hyperplastic polyp(P=0.031).The level of PGR increased in patients with gastric hyperplastic polyp.Conclusions:1.When serum G-17 is positive,PG Ⅱ levels are low in patients with gastric polyps.2.The number(single/multiple)and size of gastric polyp had no significant correlation with Hp infection rate,serum G-17 and PG indexes.3.The positive rate of G-17 is low in patients with gastric body polyp and gastric fundus polyp.The level of PGR is increased in patients with gastric body polyp.4.Patients with fundic gland polyps are mostly female and older patients.The level of PGR increased in patients with gastric hyperplastic polyp.