Observation On The Clinical Efficacy Of Treating Stage Ⅲ And Ⅳ Diabetic Nephropathy Based On The Theory Of Renal Collateral Disease Pathogenesi

ObjectiveBased on the core TCM pathogenesis of diabetic kidney disease of "shenluozhengjia",giving treatment of qingrexiaozheng dialectical treatment.Observing the curative effect to further prove the effectiveness and safety of the rules and therapeutic methods based on the pathogenesis theory of this disease.MethodsThis topic adopts a random,controlled and open research method.65 cases of diabetic kidney disease of the early and middle stage were randomly divided into two groups,35 cases in the experimental group and 30 in the control group.Two cases of control group shedded.The control group was treated with basical western medicine,and the experimental group was treated with traditional basical western medicine and traditional Chinese medicine treatment of qingrexiaozheng therapy.Doctors should follow up the patients at the zeroth weeks,fourth weeks,twelfth weeks,and twenty-fourth weeks,respectively.At every visite,the patients shoud receive the education of chronic disease.And the doctors should record the patients’ follow-up information,in addition to the general information,vital signs,the height,weight,waist circumference and changes in drug used were also needed to be recorded.During each follow-up period,routine blood tests,urine routine,biochemical,electrocardiogram,glycosylated hemoglobin,C peptide/insulin of the patients should be tested.The doctors did the evaluation of the symptom scale of Chinese medicine and the assessment of the quality of life scale.ResultsThere was no difference in age,blood pressure and BMI between the control group and the treatment group.The total urine protein in the 24 hours of the trial group showed a more obvious upward trend compared with the control group.After treatment for fourth weeks,Twelfth weeks and twenty-fourth weeks,the TCM syndrome scores in the experimental group decreased compared with those before treatment,and the P values were all less than 0.01,the difference was statistically significant.After treatment for twenty-fourth weeks,the glycosylated hemoglobin in the test group was lower than that in the control group,P<0.05,the difference was statistically significant;the VAS score of the EQ-5D-5L scale in the trial group was higher than that before treatment,P<0.01,the difference was statistically significant.The scores of physiological function,mental health and emotional function of the KDQOL-SF scale of the trial group were higher than those before treatment,and the P values were less than 0.05,the difference was statistically significant.There was no significant difference in blood routine and liver function between the experimental group and the control group.ConclusionThe treatments based on the "shenluozhengjia theory"of diabetic kidney disease can delay the progression of urinary protein to a certain extent.lt is superior to mere western medicine in the control of blood glucose level,improvement of symptoms and quality of life.And to a certain extent,the treatmeat can improve the level of oxidative stress with good security.